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LPA Receptors: Subtypes and Biological Actions

JI WOONG CHOI ; HERR, Deron R ; CHUN, Jerold ; NOGUCHI, Kyoko ; YUNG, Yun C ; LEE, Chang-Wook ; MUTOH, Tetsuji ; LIN, Mu-En ; TEO, Siew T ; PARK, Kristine E ; MOSLEY, Alycia N

Annual review of pharmacology and toxicology, 2010-02, Vol.50 (1), p.157-186 [Periódico revisado por pares]

Palo Alto, CA: Annual Reviews

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Título:
LPA Receptors: Subtypes and Biological Actions
Autor: JI WOONG CHOI ; HERR, Deron R ; CHUN, Jerold ; NOGUCHI, Kyoko ; YUNG, Yun C ; LEE, Chang-Wook ; MUTOH, Tetsuji ; LIN, Mu-En ; TEO, Siew T ; PARK, Kristine E ; MOSLEY, Alycia N
Assuntos: Animals ; Biological and medical sciences ; Cardiovascular Physiological Phenomena ; Cell receptors ; Cell structures and functions ; Fibrosis ; Fundamental and applied biological sciences. Psychology ; Humans ; Immune System - physiology ; Lysophospholipids - metabolism ; Miscellaneous ; Molecular and cellular biology ; Neoplasms - etiology ; Nervous System Physiological Phenomena ; Obesity - etiology ; Receptors, Lysophosphatidic Acid - agonists ; Receptors, Lysophosphatidic Acid - antagonists & inhibitors ; Receptors, Lysophosphatidic Acid - classification ; Receptors, Lysophosphatidic Acid - physiology ; Reproduction ; Signal Transduction
É parte de: Annual review of pharmacology and toxicology, 2010-02, Vol.50 (1), p.157-186
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Descrição: Lysophosphatidic acid (LPA) is a small, ubiquitous phospholipid that acts as an extracellular signaling molecule by binding to and activating at least five known G protein-coupled receptors (GPCRs): LPA(1)-LPA(5). They are encoded by distinct genes named LPAR1-LPAR5 in humans and Lpar1-Lpar5 in mice. The biological roles of LPA are diverse and include developmental, physiological, and pathophysiological effects. This diversity is mediated by broad and overlapping expression patterns and multiple downstream signaling pathways activated by cognate LPA receptors. Studies using cloned receptors and genetic knockout mice have been instrumental in uncovering the significance of this signaling system, notably involving basic cellular processes as well as multiple organ systems such as the nervous system. This has further provided valuable proof-of-concept data to support LPA receptors and LPA metabolic enzymes as targets for the treatment of medically important diseases that include neuropsychiatric disorders, neuropathic pain, infertility, cardiovascular disease, inflammation, fibrosis, and cancer.
Editor: Palo Alto, CA: Annual Reviews
Idioma: Inglês

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LPA Receptors: Subtypes and Biological Actions

JI WOONG CHOI ; HERR, Deron R ; CHUN, Jerold ; NOGUCHI, Kyoko ; YUNG, Yun C ; LEE, Chang-Wook ; MUTOH, Tetsuji ; LIN, Mu-En ; TEO, Siew T ; PARK, Kristine E ; MOSLEY, Alycia N

Palo Alto, CA: Annual Reviews

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