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Adiponectin-11377CG gene polymorphism and type 2 diabetes mellitus in the Chinese population: a meta-analysis of 6425 subjects

Li, Yan-Yan ; Yang, Zhi-Jian ; Zhou, Chuan-Wei ; Wang, Xiang-Ming ; Qian, Yun ; Xu, Jian ; Wang, Bei ; Wu, Jun Buzzetti, Raffaella

PloS one, 2013-04, Vol.8 (4), p.e61153-e61153 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Adiponectin-11377CG gene polymorphism and type 2 diabetes mellitus in the Chinese population: a meta-analysis of 6425 subjects
Autor: Li, Yan-Yan ; Yang, Zhi-Jian ; Zhou, Chuan-Wei ; Wang, Xiang-Ming ; Qian, Yun ; Xu, Jian ; Wang, Bei ; Wu, Jun
Buzzetti, Raffaella
Assuntos: 5' Untranslated Regions ; Adipocytes ; Adiponectin ; Adiponectin - genetics ; Adult ; Aged ; Alleles ; Analysis ; Asian Continental Ancestry Group ; Binding sites ; Biology ; Confidence intervals ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus, Type 2 - ethnology ; Diabetes Mellitus, Type 2 - genetics ; Female ; Gene Frequency ; Gene polymorphism ; Genetic aspects ; Genetic polymorphisms ; Genetic Predisposition to Disease ; Geriatrics ; Health risks ; Hospitals ; Humans ; Inflammation ; Insulin ; Male ; Medicine ; Meta-analysis ; Metabolism ; Middle Aged ; Obesity ; Odds Ratio ; Oxidative stress ; Polymorphism ; Polymorphism, Genetic ; Population ; Proteins ; Risk ; Studies ; Systematic review ; Type 2 diabetes
É parte de: PloS one, 2013-04, Vol.8 (4), p.e61153-e61153
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
Conceived and designed the experiments: YL CZ ZY. Performed the experiments: YL JX. Analyzed the data: YL YQ BW. Contributed reagents/materials/analysis tools: YL XW JW. Wrote the paper: YL.
Competing Interests: The authors have declared that no competing interests exist.
Descrição: Although adiponectin -11377CG gene polymorphism is implied to be associated with increased type 2 diabetes mellitus (T2DM) risk, results of individual studies are inconsistent. A meta-analysis consisting of 12 individual studies, including a total of 6425 participants, was carried out in order to investigate the association of adiponectin -11377CG gene polymorphism with T2DM. The pooled odds ratio (OR) and its corresponding confidence interval (CI) at 95% were assessed through the random- or fixed- effect model. A significant relationship was observed between adiponectin -11377CG gene polymorphism and T2DM under allelic (OR: 1.150, 95% CI: 1.060 to 1.250, P = 0.001), recessive (OR: 1.450, 95% CI: 1.180-1.770, P = 0.0004), dominant (OR: 1.071, 95% CI: 1.013-1.131, P = 0.015), additive (OR: 1.280, 95% CI: 1.090-1.510, P = 0.002), and homozygous genetic models (OR: 1.620, 95% CI: 1.310-1.990, P<0.00001). No significant association was found between them under the heterozygous genetic model (OR: 1.640, 95% CI: 0.850-3.170, P = 0.140). Adiponectin -11377CG gene polymorphism was significantly associated with T2DM risk susceptibility. G allele carriers are predisposed to T2DM risk.
Editor: United States: Public Library of Science
Idioma: Inglês

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Adiponectin-11377CG gene polymorphism and type 2 diabetes mellitus in the Chinese population: a meta-analysis of 6425 subjects

Li, Yan-Yan ; Yang, Zhi-Jian ; Zhou, Chuan-Wei ; Wang, Xiang-Ming ; Qian, Yun ; Xu, Jian ; Wang, Bei ; Wu, Jun Buzzetti, Raffaella

United States: Public Library of Science

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