skip to main content
Idioma:

Bone-cartilage crosstalk： a conversation for understanding osteoarthritis

Findlay, David M ; Kuliwaba, Julia S

Bone Research, 2016-09, Vol.4 (3), p.121-132, Article 16028 [Periódico revisado por pares]

China: Springer Nature B.V

Texto completo disponível

Citações Citado por
  • Título:
    Bone-cartilage crosstalk： a conversation for understanding osteoarthritis
  • Autor: Findlay, David M ; Kuliwaba, Julia S
  • Assuntos: Review
  • É parte de: Bone Research, 2016-09, Vol.4 (3), p.121-132, Article 16028
  • Notas: 51-1745/R
    Although cartilage degradation is the characteristic feature of osteoarthritis （OA）, it is now recognized that the whole joint is involved in the progression of OA. In particular, the interaction （crosstalk） between cartilage and subchondral bone is thought to be a central feature of this process. The interface between articular cartilage and bone of articulating long bones is a unique zone, which comprises articular cartilage, below which is the calcified cartilage sitting on and intercalated into the subchondral bone plate. Below the subchondral plate is the trabecular bone at the end of the respective long bones. In OA, there are well- char described p.rogressive destructive tges in the ~cular cartilage, which parallel characteristic changes in the underlying hone, This review examines the evidence that biochemical and biomechanical signaling between these tissue compartments is important in OA disease progression and asks whether such signaling might provide possibilities for therapeutic intervention to halt or slow disease development.
    ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
  • Descrição: Although cartilage degradation is the characteristic feature of osteoarthritis （OA）, it is now recognized that the whole joint is involved in the progression of OA. In particular, the interaction （crosstalk） between cartilage and subchondral bone is thought to be a central feature of this process. The interface between articular cartilage and bone of articulating long bones is a unique zone, which comprises articular cartilage, below which is the calcified cartilage sitting on and intercalated into the subchondral bone plate. Below the subchondral plate is the trabecular bone at the end of the respective long bones. In OA, there are well- char described p.rogressive destructive tges in the ~cular cartilage, which parallel characteristic changes in the underlying hone, This review examines the evidence that biochemical and biomechanical signaling between these tissue compartments is important in OA disease progression and asks whether such signaling might provide possibilities for therapeutic intervention to halt or slow disease development.
  • Editor: China: Springer Nature B.V
  • Idioma: Chinês;Inglês
Links
Voltar para lista de resultados

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.