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Personalized Medicine: What’s in it for Rare Diseases?

Schee genannt Halfmann, Sebastian ; Mählmann, Laura ; Leyens, Lada ; Reumann, Matthias ; Brand, Angela Groft, Stephen C. ; Taruscio, Domenica ; Posada de la Paz, Manuel

Advances in experimental medicine and biology, 2017, Vol.1031, p.387-404 [Periódico revisado por pares]

Cham: Springer International Publishing

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Título:
Personalized Medicine: What’s in it for Rare Diseases?
Autor: Schee genannt Halfmann, Sebastian ; Mählmann, Laura ; Leyens, Lada ; Reumann, Matthias ; Brand, Angela
Groft, Stephen C. ; Taruscio, Domenica ; Posada de la Paz, Manuel
Assuntos: Actionable big data analytics ; Data Mining ; Databases, Factual ; Genetic Predisposition to Disease ; Genomics - methods ; Health data cooperatives ; Humans ; Managed entry agreement ; Personalized medicine ; Phenotype ; Precision Medicine - methods ; Predictive Value of Tests ; Prognosis ; Rare disease ; Rare Diseases - diagnosis ; Rare Diseases - epidemiology ; Rare Diseases - genetics ; Rare Diseases - therapy ; Registries ; Risk Factors ; Systematic early dialogue ; Translational Medical Research - methods
É parte de: Advances in experimental medicine and biology, 2017, Vol.1031, p.387-404
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: Personalised Medicine has become a reality over the last years. The emergence of ‘omics’ and big data has started revolutionizing healthcare. New ‘omics’ technologies lead to a better molecular characterization of diseases and a new understanding of the complexity of diseases. The approach of PM is already successfully applied in different healthcare areas such as oncology, cardiology, nutrition and for rare diseases. However, health systems across the EU are often still promoting the ‘one-size fits all’ approach, even if it is known that patients do greatly vary in their molecular characteristics and response to drugs and other interventions. To make use of the full potentials of PM in the next years ahead several challenges need to be addressed such as the integration of big data, patient empowerment, translation of basic to clinical research, bringing the innovation to the market and shaping sustainable healthcare systems.
Editor: Cham: Springer International Publishing
Idioma: Inglês

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Personalized Medicine: What’s in it for Rare Diseases?

Schee genannt Halfmann, Sebastian ; Mählmann, Laura ; Leyens, Lada ; Reumann, Matthias ; Brand, Angela Groft, Stephen C. ; Taruscio, Domenica ; Posada de la Paz, Manuel

Cham: Springer International Publishing

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