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Thromboinflammation in Therapeutic Medicine

Ekdahl, Kristina N. ; Teramura, Yuji ; Asif, Sana ; Jonsson, Nina ; Magnusson, Peetra U. ; Nilsson, Bo

Advances in Experimental Medicine and Biology, 2015-01, Vol.865, p.3-17 [Periódico revisado por pares]

Cham: Springer International Publishing

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Título:
Thromboinflammation in Therapeutic Medicine
Autor: Ekdahl, Kristina N. ; Teramura, Yuji ; Asif, Sana ; Jonsson, Nina ; Magnusson, Peetra U. ; Nilsson, Bo
Assuntos: Anticoagulants - therapeutic use ; Biocompatible Materials - adverse effects ; Blood Coagulation - drug effects ; Blood Coagulation Factors - immunology ; Blood Coagulation Factors - metabolism ; Blood Platelets - cytology ; Blood Platelets - drug effects ; Blood Platelets - immunology ; Coagulation ; Complement ; Complement System Proteins - immunology ; Complement System Proteins - metabolism ; Endothelial Cells - cytology ; Endothelial Cells - drug effects ; Endothelial Cells - immunology ; Extracorporeal treatment ; Graft Rejection - immunology ; Graft Rejection - pathology ; Graft Rejection - prevention & control ; Humans ; Immunity, Humoral - drug effects ; Immunity, Innate - drug effects ; Immunologi ; Immunologic Factors - therapeutic use ; Immunology ; Inflammation - immunology ; Inflammation - pathology ; Inflammation - prevention & control ; Leukocytes - cytology ; Leukocytes - drug effects ; Leukocytes - immunology ; Platelets ; Therapeutic medicine ; Thromboinflammation ; Thrombosis - immunology ; Thrombosis - pathology ; Thrombosis - prevention & control ; Tissue Transplantation
É parte de: Advances in Experimental Medicine and Biology, 2015-01, Vol.865, p.3-17
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
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Descrição: Thromboinflammation is primarily triggered by the humoral innate immune system, which mainly consists of the cascade systems of the blood, i.e., the complement, contact/coagulation and fibrinolytic systems. Activation of these systems subsequently induces activation of endothelial cells, leukocytes and platelets, finally resulting in thrombotic and inflammatory reactions. Such reactions are triggered by a number of medical procedures, e.g., treatment with biomaterials or drug delivery devices as well as in transplantation with cells, cell clusters or whole vascularized organs. Here, we (1) describe basic mechanisms for thromboinflammation; (2) review thromboinflammatory reactions in therapeutic medicine; and (3) discuss emerging strategies to dampen thromboinflammation.
Editor: Cham: Springer International Publishing
Idioma: Inglês

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Thromboinflammation in Therapeutic Medicine

Ekdahl, Kristina N. ; Teramura, Yuji ; Asif, Sana ; Jonsson, Nina ; Magnusson, Peetra U. ; Nilsson, Bo

Cham: Springer International Publishing

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