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Effects of trace metal ions on secondary metabolism and the morphological development of streptomycetes

Locatelli, Fabricio M ; Goo, Kian-Sim ; Ulanova, Dana

Metallomics, 2016-05, Vol.8 (5), p.469-48 [Periódico revisado por pares]

England

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  • Título:
    Effects of trace metal ions on secondary metabolism and the morphological development of streptomycetes
  • Autor: Locatelli, Fabricio M ; Goo, Kian-Sim ; Ulanova, Dana
  • Assuntos: Metals - pharmacology ; Streptomyces - drug effects ; Streptomyces - growth & development ; Streptomycetes ; Trace Elements - pharmacology
  • É parte de: Metallomics, 2016-05, Vol.8 (5), p.469-48
  • Notas: Kian-Sim Goo obtained his PhD degree from the Department of Microbiology, National University of Singapore, in 2012. His research interest lies in antibacterial discovery, biosynthesis and resistance. He is currently working as a Scientist at Procter and Gamble Singapore Innovation Center.
    Fabricio M. Locatelli is a biologist who holds a PhD degree in Medical Sciences from Kochi University, Japan. In 2014, he joined Dr Ulanova's Laboratory as a Postdoctoral fellow to investigate the genetic material from marine microorganisms in order to identify novel genes for biosynthesis of bioactive compounds.
    Dana Ulanova received her PhD degree in Microbiology at the Charles University in Prague, under the supervision of Dr Jiri Janata, in 2009. The same year she joined the group of Prof. Takuya Nihira at Osaka University as a postdoctoral researcher. In 2011, she was appointed as an assistant professor at Kochi University. Her research focuses on natural product biosynthesis and regulation in marine and soil actinomycetes.
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  • Descrição: Bacteria belonging to the Streptomyces genus are characterized by a complex life cycle and the production of many bioactive secondary metabolites. Trace metals play an important role in streptomycete metabolism and development, however, their mechanism of action is not fully understood. In this review, we summarize the present knowledge on metallosensing regulators and trace metal action, as well as discuss the possible application in natural product discovery. Bacteria belonging to the Streptomyces genus are characterized by a complex life cycle and the production of many bioactive secondary metabolites.
  • Editor: England
  • Idioma: Inglês
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