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Remodeling the Integration of Lipid Metabolism Between Liver and Adipose Tissue by Dietary Methionine Restriction in Rats

HASEK, Barbara E ; BOUDREAU, Anik ; GHOSH, Sujoy ; PESSIN, Jeffrey E ; GETTYS, Thomas W ; JEHO SHIN ; DAORONG FENG ; HULVER, Matthew ; VAN, Nancy T ; LAQUE, Amanda ; STEWART, Laura K ; STONE, Kirsten P ; WANDERS, Desiree

Diabetes (New York, N.Y.), 2013-10, Vol.62 (10), p.3362-3372 [Periódico revisado por pares]

Alexandria, VA: American Diabetes Association

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Título:
Remodeling the Integration of Lipid Metabolism Between Liver and Adipose Tissue by Dietary Methionine Restriction in Rats
Autor: HASEK, Barbara E ; BOUDREAU, Anik ; GHOSH, Sujoy ; PESSIN, Jeffrey E ; GETTYS, Thomas W ; JEHO SHIN ; DAORONG FENG ; HULVER, Matthew ; VAN, Nancy T ; LAQUE, Amanda ; STEWART, Laura K ; STONE, Kirsten P ; WANDERS, Desiree
Assuntos: Adipose tissue ; Adipose Tissue, White - metabolism ; Adipose tissues ; Amino acids ; Analysis ; Animals ; Biological and medical sciences ; Biomarkers - metabolism ; Blotting, Western ; Diabetes. Impaired glucose tolerance ; Diet ; Down-Regulation ; Eating ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Energy Metabolism ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Fatty Acids - metabolism ; Gene Expression ; Genes ; Health aspects ; Insulin Resistance ; Leucine - deficiency ; Lipid Metabolism ; Lipids ; Liver ; Liver - metabolism ; Male ; Medical sciences ; Metabolism ; Methionine - deficiency ; Mitochondria - metabolism ; Original Research ; Rats ; Rats, Inbred F344 ; Real-Time Polymerase Chain Reaction ; Rodents ; Tissues
É parte de: Diabetes (New York, N.Y.), 2013-10, Vol.62 (10), p.3362-3372
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Dietary methionine restriction (MR) produces an integrated series of biochemical and physiological responses that improve biomarkers of metabolic health, limit fat accretion, and enhance insulin sensitivity. Using transcriptional profiling to guide tissue-specific evaluations of molecular responses to MR, we report that liver and adipose tissue are the primary targets of a transcriptional program that remodeled lipid metabolism in each tissue. The MR diet produced a coordinated downregulation of lipogenic genes in the liver, resulting in a corresponding reduction in the capacity of the liver to synthesize and export lipid. In contrast, the transcriptional response in white adipose tissue (WAT) involved a depot-specific induction of lipogenic and oxidative genes and a commensurate increase in capacity to synthesize and oxidize fatty acids. These responses were accompanied by a significant change in adipocyte morphology, with the MR diet reducing cell size and increasing mitochondrial density across all depots. The coordinated transcriptional remodeling of lipid metabolism between liver and WAT by dietary MR produced an overall reduction in circulating and tissue lipids and provides a potential mechanism for the increase in metabolic flexibility and enhanced insulin sensitivity produced by the diet.
Editor: Alexandria, VA: American Diabetes Association
Idioma: Inglês

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Remodeling the Integration of Lipid Metabolism Between Liver and Adipose Tissue by Dietary Methionine Restriction in Rats

HASEK, Barbara E ; BOUDREAU, Anik ; GHOSH, Sujoy ; PESSIN, Jeffrey E ; GETTYS, Thomas W ; JEHO SHIN ; DAORONG FENG ; HULVER, Matthew ; VAN, Nancy T ; LAQUE, Amanda ; STEWART, Laura K ; STONE, Kirsten P ; WANDERS, Desiree

Alexandria, VA: American Diabetes Association

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