Idioma:

Fracture fixation in the operative management of hip fractures (FAITH): an international, multicentre, randomised controlled trial

Oatt, Amber ; Karlsten, Anders ; Marcantonio, Andrew J. ; Rai, Anil ; Zurcher, Arthur W. ; Jain, Arvind ; Hileman, Barbara ; Verhoeven, Bart ; Fioole, Bram ; Richardson, C. Glen ; Bowler, Carol ; Humphrey, Catherine A. ; Koppert, Cees L. ; DePaolo, Charles J. ; Anderson, Christopher G. ; van der Hart, Cor P. ; Stinner, Daniel ; Viskontas, Darius ; Karges, David E. ; Johnston, David ; Yen, David ; Olakkengil, Davy J ; Donegan, Derek ; Nam, Diane ; Li, Doug ; Tan, Edward T.C.H. ; Schemitsch, Emil H. ; Hammacher, Eric R. ; Torres, Erick T. ; Howells, Fiona ; Gudger, Garland K. ; Wood, Gavin ; Hjorthaug, Geir ; Rieser, Geoffrey Ryan ; Chuter, Graham ; Rocca, Gregory J. Della ; Dobbin, Gwendolyn ; Kuiken, Hans ; Rijna, Herman ; Rajakumar, Janakiraman ; Baker, Janell K. ; de Vries, Jean Paul P.M. ; May, Jedediah ; Hoffman, Jodi M. ; Cherian, Joe Joseph ; Clarke-Jenssen, John ; Adams, John D. ; Gorczyca, John T. ; Foret, Jonathan L. ; Keeve, Jonathan P. ; Scheepers, Joris J.G. ; Baele, Joseph ; Cass, Joseph R. ; Turckan, Kahn ; Rai, Kamal ; van Wessem, Karlijn ; Kruse, Kevin K. ; Browner, Kieran ; Lyle, Lindsey ; Pilling, Lindsey ; Buckingham, Lisa ; de Waal Malefijt, Maarten C. ; Bronkhorst, Maarten W.G.A. ; Lobo, Margaret J. ; Swinton, Marilyn ; Tynan, Martin C. ; Heetveld, Martin J. ; Esser, Max ; Peters, Melissa E. ; Dunbar, Michael ; Beckish, Michael L. ; Brennan, Michael L. ; Kain, Michael S.H. ; Vogt, Michelle ; Bruijninckx, Milko M.M. ; Palla, Naveen ; Schep, Niels W.L. ; Seuffert, Patricia ; Zalzal, Paul ; Kregor, Philip ; Oprel, Pim ; Snider, Rebecca G. ; Farrugia, Richard J ; Korley, Robert ; Probe, Robert ; Wessel, Ronald N. ; Miller, Russell ; Finnan, Ryan ; Puloski, Shannon ; Zielinski, Stephanie M. ; Papp, Steve ; Hollenbeck, Steven M. ; Weinerman, Stuart ; Lambert, Sue ; Lona, Tarjei ; van Egmond, Teun ; Naumetz, V. ; Ghent, Wesley ; Cross, William W. ; Murdoch, Zoe

The Lancet (British edition), 2017-04, Vol.389 (10078), p.1519-1527 [Periódico revisado por pares]

England: Elsevier Ltd

Texto completo disponível

Citações Citado por

Enviar para

Título:
Fracture fixation in the operative management of hip fractures (FAITH): an international, multicentre, randomised controlled trial
Autor: Oatt, Amber ; Karlsten, Anders ; Marcantonio, Andrew J. ; Rai, Anil ; Zurcher, Arthur W. ; Jain, Arvind ; Hileman, Barbara ; Verhoeven, Bart ; Fioole, Bram ; Richardson, C. Glen ; Bowler, Carol ; Humphrey, Catherine A. ; Koppert, Cees L. ; DePaolo, Charles J. ; Anderson, Christopher G. ; van der Hart, Cor P. ; Stinner, Daniel ; Viskontas, Darius ; Karges, David E. ; Johnston, David ; Yen, David ; Olakkengil, Davy J ; Donegan, Derek ; Nam, Diane ; Li, Doug ; Tan, Edward T.C.H. ; Schemitsch, Emil H. ; Hammacher, Eric R. ; Torres, Erick T. ; Howells, Fiona ; Gudger, Garland K. ; Wood, Gavin ; Hjorthaug, Geir ; Rieser, Geoffrey Ryan ; Chuter, Graham ; Rocca, Gregory J. Della ; Dobbin, Gwendolyn ; Kuiken, Hans ; Rijna, Herman ; Rajakumar, Janakiraman ; Baker, Janell K. ; de Vries, Jean Paul P.M. ; May, Jedediah ; Hoffman, Jodi M. ; Cherian, Joe Joseph ; Clarke-Jenssen, John ; Adams, John D. ; Gorczyca, John T. ; Foret, Jonathan L. ; Keeve, Jonathan P. ; Scheepers, Joris J.G. ; Baele, Joseph ; Cass, Joseph R. ; Turckan, Kahn ; Rai, Kamal ; van Wessem, Karlijn ; Kruse, Kevin K. ; Browner, Kieran ; Lyle, Lindsey ; Pilling, Lindsey ; Buckingham, Lisa ; de Waal Malefijt, Maarten C. ; Bronkhorst, Maarten W.G.A. ; Lobo, Margaret J. ; Swinton, Marilyn ; Tynan, Martin C. ; Heetveld, Martin J. ; Esser, Max ; Peters, Melissa E. ; Dunbar, Michael ; Beckish, Michael L. ; Brennan, Michael L. ; Kain, Michael S.H. ; Vogt, Michelle ; Bruijninckx, Milko M.M. ; Palla, Naveen ; Schep, Niels W.L. ; Seuffert, Patricia ; Zalzal, Paul ; Kregor, Philip ; Oprel, Pim ; Snider, Rebecca G. ; Farrugia, Richard J ; Korley, Robert ; Probe, Robert ; Wessel, Ronald N. ; Miller, Russell ; Finnan, Ryan ; Puloski, Shannon ; Zielinski, Stephanie M. ; Papp, Steve ; Hollenbeck, Steven M. ; Weinerman, Stuart ; Lambert, Sue ; Lona, Tarjei ; van Egmond, Teun ; Naumetz, V. ; Ghent, Wesley ; Cross, William W. ; Murdoch, Zoe
Assuntos: Aged ; Aged, 80 and over ; Avascular necrosis ; Biomechanics ; Bone healing ; Bone Screws ; Clinical trials ; Data processing ; Embolism ; Equipment Design ; Evidence-based medicine ; Female ; Femoral Neck Fractures - surgery ; Femur Head Necrosis - etiology ; Fixation ; Fracture Fixation, Internal - adverse effects ; Fracture Fixation, Internal - instrumentation ; Fracture Fixation, Internal - methods ; Fracture Healing ; Fractures ; Healing ; Health ; Hip ; Hip joint ; Humans ; Infections ; Internal Medicine ; Joint surgery ; Kaplan-Meier Estimate ; Male ; Medical personnel ; Motivation ; Neck ; Pain ; Patients ; Physicians ; Quality of Life ; R&D ; Randomization ; Reoperation - statistics & numerical data ; Research & development ; Screws ; Sepsis ; Single-Blind Method ; Sliding ; Smoking ; Surgeons ; Surgery ; Surgical outcomes ; Surgical techniques ; Treatment Outcome
É parte de: The Lancet (British edition), 2017-04, Vol.389 (10078), p.1519-1527
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ObjectType-Undefined-3
See the appendix for a full list of FAITH Trial investigators and the Contributors section for the writing committee
Descrição: Summary Background Reoperation rates are high after surgery for hip fractures. We investigated the effect of a sliding hip screw versus cancellous screws on the risk of reoperation and other key outcomes. Methods For this international, multicentre, allocation concealed randomised controlled trial, we enrolled patients aged 50 years or older with a low-energy hip fracture requiring fracture fixation from 81 clinical centres in eight countries. Patients were assigned by minimisation with a centralised computer system to receive a single large-diameter screw with a side-plate (sliding hip screw) or the present standard of care, multiple small-diameter cancellous screws. Surgeons and patients were not blinded but the data analyst, while doing the analyses, remained blinded to treatment groups. The primary outcome was hip reoperation within 24 months after initial surgery to promote fracture healing, relieve pain, treat infection, or improve function. Analyses followed the intention-to-treat principle. This study was registered with ClinicalTrials.gov , number NCT00761813. Findings Between March 3, 2008, and March 31, 2014, we randomly assigned 1108 patients to receive a sliding hip screw (n=557) or cancellous screws (n=551). Reoperations within 24 months did not differ by type of surgical fixation in those included in the primary analysis: 107 (20%) of 542 patients in the sliding hip screw group versus 117 (22%) of 537 patients in the cancellous screws group (hazard ratio [HR] 0·83, 95% CI 0·63–1·09; p=0·18). Avascular necrosis was more common in the sliding hip screw group than in the cancellous screws group (50 patients [9%] vs 28 patients [5%]; HR 1·91, 1·06–3·44; p=0·0319). However, no significant difference was found between the number of medically related adverse events between groups (p=0·82; appendix ); these events included pulmonary embolism (two patients [<1%] vs four [1%] patients; p=0·41) and sepsis (seven [1%] vs six [1%]; p=0·79). Interpretation In terms of reoperation rates the sliding hip screw shows no advantage, but some groups of patients (smokers and those with displaced or base of neck fractures) might do better with a sliding hip screw than with cancellous screws. Funding National Institutes of Health, Canadian Institutes of Health Research, Stichting NutsOhra, Netherlands Organisation for Health Research and Development, Physicians' Services Incorporated.
Editor: England: Elsevier Ltd
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Fracture fixation in the operative management of hip fractures (FAITH): an international, multicentre, randomised controlled trial

England: Elsevier Ltd

Buscando em bases de dados remotas. Favor aguardar.