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Veterinary pharmacovigilance in sub-Sahara Africa context: a pilot study of adverse reactions to veterinary medicine in Cameroon

Mouiche, Mohamed Moctar Mouliom ; Njingou, Badou Zaki Ndouoya ; Moffo, Frédéric ; Mpouam, Serge Eugene ; Feussom, Jean Marc Kameni ; Awah-Ndukum, Julius

BMC veterinary research, 2019-08, Vol.15 (1), p.301-8, Article 301 [Periódico revisado por pares]

England: BioMed Central Ltd

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Título:
Veterinary pharmacovigilance in sub-Sahara Africa context: a pilot study of adverse reactions to veterinary medicine in Cameroon
Autor: Mouiche, Mohamed Moctar Mouliom ; Njingou, Badou Zaki Ndouoya ; Moffo, Frédéric ; Mpouam, Serge Eugene ; Feussom, Jean Marc Kameni ; Awah-Ndukum, Julius
Assuntos: Actors ; Adverse drug reactions ; Adverse drugs reactions ; Africa South of the Sahara ; Animal Diseases - chemically induced ; Animal Diseases - epidemiology ; Animals ; Beef cattle ; Cameroon ; Cameroon - epidemiology ; Causes of ; Complications and side effects ; Counterfeit Drugs - adverse effects ; Cross-Sectional Studies ; Data Collection ; Demographic aspects ; Dogs ; Drug counterfeiting ; Drugs ; Health aspects ; Identification and classification ; Inefficacy ; Ivermectin ; Legislation, Drug ; Levamisole ; Marketing ; Medical personnel ; Oxytetracycline ; Pharmacovigilance ; Pilot Projects ; Product counterfeiting ; Reporting ; Retirement benefits ; Veterinary drugs ; Veterinary Drugs - adverse effects ; Veterinary medicine
É parte de: BMC veterinary research, 2019-08, Vol.15 (1), p.301-8, Article 301
Descrição: Sub-Saharan African market is highly affected by counterfeit veterinary drugs. Though these counterfeit and non-compliance of drugs can induce adverse effects during their utilization, there is no monitoring system of veterinary medicines. The present pilot study was carried out in Cameroon to identify and describe suspected cases of adverse reactions to veterinary drugs in animals and / or humans as well as inefficacy of veterinary drugs. The methodology involved a descriptive cross-sectional survey of 67 actors in the veterinary medicine sector in Cameroon. A total of 74/120 (62%) cases of suspected adverse effects and or lack of efficacy of veterinary drugs in animals and 46 (38%) cases of adverse reactions in humans were identified. Antiparasitics were the most incriminated therapeutic class in animals (61%) and human (56%). Adverse reactions were reported in dogs (44%) and poultry (24%) while drug inefficacy was most observed in poultry (47%). According to animal health professionals, levamisole (24%) and ivermectin (16%) were identified to be responsible for the adverse effects and that the highest level of inefficacy was most frequently reported for oxytetracycline (29%). The main adverse reactions were systemic (22%), gastrointestinal (20%) and neurological (13%) disorders. The results of this study showed that misuse and circulation of poor quality as well as lack of efficacy of veterinary drugs is very common in Cameroon. Adverse reactions were observed in animals and humans. Therefore, the establishment of a national veterinary pharmacovigilance system based on solid legal bases is essential for a continuous assessment of the risks-benefits effects of veterinary drugs marketed in Cameroon.
Editor: England: BioMed Central Ltd
Idioma: Inglês

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Veterinary pharmacovigilance in sub-Sahara Africa context: a pilot study of adverse reactions to veterinary medicine in Cameroon

Mouiche, Mohamed Moctar Mouliom ; Njingou, Badou Zaki Ndouoya ; Moffo, Frédéric ; Mpouam, Serge Eugene ; Feussom, Jean Marc Kameni ; Awah-Ndukum, Julius

England: BioMed Central Ltd

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