Idioma:

Bacterial and fungal coinfection among hospitalized patients with COVID-19: a retrospective cohort study in a UK secondary-care setting

Hughes, S. ; Troise, O. ; Donaldson, H. ; Mughal, N. ; Moore, L.S.P.

Clinical microbiology and infection, 2020-10, Vol.26 (10), p.1395-1399 [Periódico revisado por pares]

England: Elsevier Ltd

Sem texto completo

Citações Citado por

Enviar para

Título:
Bacterial and fungal coinfection among hospitalized patients with COVID-19: a retrospective cohort study in a UK secondary-care setting
Autor: Hughes, S. ; Troise, O. ; Donaldson, H. ; Mughal, N. ; Moore, L.S.P.
Assuntos: Age Factors ; Aged ; Aged, 80 and over ; Antimicrobial Stewardship ; Bacterial co-infection ; Bacterial Infections - diagnosis ; Bacterial Infections - epidemiology ; Bacterial Infections - microbiology ; Bacterial Infections - virology ; Betacoronavirus - pathogenicity ; Coinfection ; Community-Acquired Infections ; Coronavirus ; Coronavirus Infections - diagnosis ; Coronavirus Infections - epidemiology ; Coronavirus Infections - microbiology ; Coronavirus Infections - virology ; COVID-19 ; Female ; Hospitalization ; Humans ; Influenza, Human - diagnosis ; Influenza, Human - epidemiology ; Influenza, Human - microbiology ; Influenza, Human - virology ; Male ; Middle Aged ; Mycoses - diagnosis ; Mycoses - epidemiology ; Mycoses - microbiology ; Mycoses - virology ; Original ; Pandemics ; Pneumonia ; Pneumonia, Viral - diagnosis ; Pneumonia, Viral - epidemiology ; Pneumonia, Viral - microbiology ; Pneumonia, Viral - virology ; Respiratory Tract Infections - diagnosis ; Respiratory Tract Infections - epidemiology ; Respiratory Tract Infections - microbiology ; Respiratory Tract Infections - virology ; Retrospective Studies ; SARS-CoV-2 ; Severity of Illness Index ; United Kingdom - epidemiology
É parte de: Clinical microbiology and infection, 2020-10, Vol.26 (10), p.1395-1399
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Undefined-1
ObjectType-Feature-3
content type line 23
Descrição: To investigate the incidence of bacterial and fungal coinfection of hospitalized patients with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in this retrospective observational study across two London hospitals during the first UK wave of coronavirus disease 2019 (COVID-19). A retrospective case series of hospitalized patients with confirmed SARS-CoV-2 by PCR was analysed across two acute NHS hospitals (20 February–20 April 2020; each isolate reviewed independently in parallel). This was contrasted to a control group of influenza-positive patients admitted during the 2019–2020 flu season. Patient demographics, microbiology and clinical outcomes were analysed. A total of 836 patients with confirmed SARS-CoV-2 were included; 27 (3.2%) of 836 had early confirmed bacterial isolates identified (0–5 days after admission), rising to 51 (6.1%) of 836 throughout admission. Blood cultures, respiratory samples, pneumococcal or Legionella urinary antigens and respiratory viral PCR panels were obtained from 643 (77%), 110 (13%), 249 (30%), 246 (29%) and 250 (30%) COVID-19 patients, respectively. A positive blood culture was identified in 60 patients (7.1%), of which 39 were classified as contaminants. Bacteraemia resulting from respiratory infection was confirmed in two cases (one each community-acquired Klebsiella pneumoniae and ventilator-associated Enterobacter cloacae). Line-related bacteraemia was identified in six patients (three Candida, two Enterococcus spp. and one Pseudomonas aeruginosa). All other community-acquired bacteraemias (n = 16) were attributed to nonrespiratory infection. Zero concomitant pneumococcal, Legionella or influenza infection was detected. A low yield of positive respiratory cultures was identified; Staphylococcus aureus was the most common respiratory pathogen isolated in community-acquired coinfection (4/24; 16.7%), with pseudomonas and yeast identified in late-onset infection. Invasive fungal infections (n = 3) were attributed to line-related infections. Comparable rates of positive coinfection were identified in the control group of confirmed influenza infection; clinically relevant bacteraemias (2/141; 1.4%), respiratory cultures (10/38; 26.3%) and pneumococcal-positive antigens (1/19; 5.3%) were low. We found a low frequency of bacterial coinfection in early COVID-19 hospital presentation, and no evidence of concomitant fungal infection, at least in the early phase of COVID-19.
Editor: England: Elsevier Ltd
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Bacterial and fungal coinfection among hospitalized patients with COVID-19: a retrospective cohort study in a UK secondary-care setting

Hughes, S. ; Troise, O. ; Donaldson, H. ; Mughal, N. ; Moore, L.S.P.

England: Elsevier Ltd

Buscando em bases de dados remotas. Favor aguardar.