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Action dominates valence in anticipatory representations in the human striatum and dopaminergic midbrain

Guitart-Masip, Marc ; Fuentemilla, Lluis ; Bach, Dominik R ; Huys, Quentin J M ; Dayan, Peter ; Dolan, Raymond J ; Duzel, Emrah

The Journal of neuroscience, 2011-05, Vol.31 (21), p.7867-7875 [Periódico revisado por pares]

United States: Society for Neuroscience

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  • Título:
    Action dominates valence in anticipatory representations in the human striatum and dopaminergic midbrain
  • Autor: Guitart-Masip, Marc ; Fuentemilla, Lluis ; Bach, Dominik R ; Huys, Quentin J M ; Dayan, Peter ; Dolan, Raymond J ; Duzel, Emrah
  • Assuntos: Adult ; Anticipation, Psychological - physiology ; Brain stimulation ; Corpus Striatum - physiology ; Dopamine - physiology ; Estimulació del cervell ; Female ; Humans ; Magnetic Resonance Imaging - methods ; Male ; Mesencephalon - physiology ; Neurofisiologia ; Neurologia ; Neurology ; Neurophysiology ; Photic Stimulation - methods ; Reaction Time - physiology ; Young Adult
  • É parte de: The Journal of neuroscience, 2011-05, Vol.31 (21), p.7867-7875
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    Author contributions: M.G.-M., L.F., D.R.B., Q.J.M.H., P.D., R.J.D., and E.D. designed research; M.G.-M. and L.F. performed research; M.G.-M. analyzed data; M.G.-M., P.D., R.J.D., and E.D. wrote the paper.
  • Descrição: The acquisition of reward and the avoidance of punishment could logically be contingent on either emitting or withholding particular actions. However, the separate pathways in the striatum for go and no-go appear to violate this independence, instead coupling affect and effect. Respect for this interdependence has biased many studies of reward and punishment, so potential action-outcome valence interactions during anticipatory phases remain unexplored. In a functional magnetic resonance imaging study with healthy human volunteers, we manipulated subjects' requirement to emit or withhold an action independent from subsequent receipt of reward or avoidance of punishment. During anticipation, in the striatum and a lateral region within the substantia nigra/ventral tegmental area (SN/VTA), action representations dominated over valence representations. Moreover, we did not observe any representation associated with different state values through accumulation of outcomes, challenging a conventional and dominant association between these areas and state value representations. In contrast, a more medial sector of the SN/VTA responded preferentially to valence, with opposite signs depending on whether action was anticipated to be emitted or withheld. This dominant influence of action requires an enriched notion of opponency between reward and punishment.
  • Editor: United States: Society for Neuroscience
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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