skip to main content
Idioma:
Primo Advanced Search
Primo Advanced Search Query Term
Primo Advanced Search Query Term
Primo Advanced Search Query Term
Primo Advanced Search prefilters
Busca Simples

Assessment of fight outcome is needed to activate socially driven transcriptional changes in the zebrafish brain

Oliveira, Rui F. ; Simões, José M. ; Teles, Magda C. ; Oliveira, Catarina R. ; Becker, Jorg D. ; Lopes, João S.

Proceedings of the National Academy of Sciences - PNAS, 2016-02, Vol.113 (5), p.E654-E661 [Periódico revisado por pares]

United States: National Academy of Sciences

Texto completo disponível

Citações Citado por
  • Título:
    Assessment of fight outcome is needed to activate socially driven transcriptional changes in the zebrafish brain
  • Autor: Oliveira, Rui F. ; Simões, José M. ; Teles, Magda C. ; Oliveira, Catarina R. ; Becker, Jorg D. ; Lopes, João S.
  • Assuntos: Animals ; Biological Sciences ; Brain ; Brain - metabolism ; Chromosomes ; Danio rerio ; Gene Expression ; Genomics ; Genotype & phenotype ; PNAS Plus ; Promoter Regions, Genetic ; Transcription factors ; Transcription, Genetic ; Zebrafish ; Zebrafish - genetics ; Zebrafish - physiology
  • É parte de: Proceedings of the National Academy of Sciences - PNAS, 2016-02, Vol.113 (5), p.E654-E661
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    2Present address: Graduate Program in Areas of Basic and Applied Biology, Abel Salazar Biomedical Sciences Institute, University of Porto, 4099-003 Porto, Portugal; and Deutsche Forschungsgemeinschaft Center for Regenerative Therapies Dresden, Cluster of Excellence, University of Technology Dresden, 01307 Dresden, Germany.
    Edited by Gene E. Robinson, University of Illinois at Urbana–Champaign, Urbana, IL, and approved December 11, 2015 (received for review July 22, 2015)
    Author contributions: R.F.O. and J.M.S. designed research; J.M.S., M.C.T., C.R.O., and J.D.B. performed research; R.F.O., J.M.S., M.C.T., J.D.B., and J.S.L. analyzed data; and R.F.O. and J.S.L. wrote the paper.
  • Descrição: Group living animals must be able to express different behavior profiles depending on their social status. Therefore, the same genotype may translate into different behavioral phenotypes through socially driven differential gene expression. However, how social information is translated into a neurogenomic response and what are the specific cues in a social interaction that signal a change in social status are questions that have remained unanswered. Here, we show for the first time, to our knowledge, that the switch between status-specific neurogenomic states relies on the assessment of fight outcome rather than just on self- or opponent-only assessment of fighting ability. For this purpose, we manipulated the perception of fight outcome in male zebrafish and measured its impact on the brain transcriptome using a zebrafish whole genome gene chip. Males fought either a real opponent, and a winner and a loser were identified, or their own image on a mirror, in which case, despite expressing aggressive behavior, males did not experience either a victory or a defeat. Massive changes in the brain transcriptome were observed in real opponent fighters, with losers displaying both a higher number of differentially expressed genes and of coexpressed gene modules than winners. In contrast, mirror fighters expressed a neurogenomic state similar to that of noninteracting fish. The genes that responded to fight outcome included immediate early genes and genes involved in neuroplasticity and epigenetic modifications. These results indicate that, even in cognitively simple organisms such as zebrafish, neurogenomic responses underlying changes in social status rely on mutual assessment of fighting ability.
  • Editor: United States: National Academy of Sciences
  • Idioma: Inglês
Links
Voltar para lista de resultados
Ir para página anteriorAnterior Resultado  5 AvançarIr para próxima página

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.