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Pemphigoid gestationis: clinical and laboratory evaluation

Cobo, Marina Flangini; Santi, Claudia Giuli; Maruta, Celina Wakisaka; Aoki, Valéria

Clinics; v. 64 n. 11 (2009); 1043-1047

Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo 2009-11-01

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  • Título:
    Pemphigoid gestationis: clinical and laboratory evaluation
  • Autor: Cobo, Marina Flangini; Santi, Claudia Giuli; Maruta, Celina Wakisaka; Aoki, Valéria
  • Assuntos: Autoimmunity; Dermatoses Of Pregnancy; Herpes Gestationis; Blistering Disease; Bp180
  • É parte de: Clinics; v. 64 n. 11 (2009); 1043-1047
  • Descrição: INTRODUCTION: Pemphigoid gestationis, also known as herpes gestationis, is a rare autoimmune blistering disease associated with pregnancy. It usually occurs during the second or third trimester, but it may be present at any stage of pregnancy or the puerperium. The clinical, histologic, and immunopathological features of pemphigoid gestationis are similar to those of the pemphigoid group of disorders. METHODS: We hereby report seven patients who were diagnosed with pemphigoid gestationis and followed at the Autoimmune Blistering Disease Clinic in the Department of Dermatology of the University of Sao Paulo Medical School between 1996 and 2008. DISCUSSION: Demographic and clinical findings, such as median age, sites of involvement, and gestational age of onset of our patients, coincide with those described in previous reports. The majority of patients (85%) exhibited complement C3 or C3 and immunoglobulin G (IgG) deposition along the basement membrane zone (BMZ) on immunofluorescence. Herpes gestationis factor (HG) factor was postitive in four out of six patients (67%), and three out of five patients recognized the bullous pemphigoid recombinant antigen (BP180) by ELISA. CONCLUSION: This study revealed a good outcome of the newborns from pemphigoid gestationis affected mothers, based on the absence of pemphigoid gestationis cutaneous lesions, mean birth weight, and normal Apgar scores and gestational age at birth.
  • Títulos relacionados: https://www.revistas.usp.br/clinics/article/view/18066/20130
  • Editor: Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
  • Data de criação/publicação: 2009-11-01
  • Formato: Adobe PDF
  • Idioma: Inglês
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