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Contribution of viral and cellular cytokines to Kaposi’s sarcoma-associated herpesvirus pathogenesis

Gasperini, Paola ; Sakakibara, Shuhei ; Tosato, Giovanna

Journal of leukocyte biology, 2008-10, Vol.84 (4), p.994-1000 [Periódico revisado por pares]

United States: Society for Leukocyte Biology

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Título:
Contribution of viral and cellular cytokines to Kaposi’s sarcoma-associated herpesvirus pathogenesis
Autor: Gasperini, Paola ; Sakakibara, Shuhei ; Tosato, Giovanna
Assuntos: Acquired Immunodeficiency Syndrome - complications ; Acquired Immunodeficiency Syndrome - drug therapy ; angiogenesis ; Animals ; Antiretroviral Therapy, Highly Active ; Cell Division ; cell migration ; Cell Survival ; Cytokines - physiology ; Disease Models, Animal ; Herpesvirus 8, Human - genetics ; Herpesvirus 8, Human - immunology ; Human herpesvirus 8 ; Humans ; Interleukin-10 - immunology ; Interleukin-6 - immunology ; Mice ; Mice, Inbred NOD ; Mice, SCID ; multicentric Castleman's disease ; primary effusion lymphoma ; Sarcoma, Kaposi - complications ; Sarcoma, Kaposi - immunology ; Sarcoma, Kaposi - pathology ; Vascular Endothelial Growth Factor A - immunology
É parte de: Journal of leukocyte biology, 2008-10, Vol.84 (4), p.994-1000
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Correspondence: Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, Building 37, Room 4124, Bethesda, MD 20892, USA. E-mail: tosatog@mail.nih.gov
Descrição: Kaposi's sarcoma (KS)‐associated herpesvirus is associated with the proliferative/malignant disorders KS, primary effusion lymphoma (PEL), and multicentric Castleman's disease (MCD) in patients with AIDS. In spite of recent advances in the treatment of KS, PEL and MCD represent therapeutic challenges. Recent advances in dissecting the pathogenesis of these diseases have indicated that the viral cytokine IL‐6 and the cellular cytokines/growth factors IL‐10, IL‐6, stromal cell‐derived factor 1, and vascular endothelial growth factor are important contributors to the growth, survival, and spread of PEL and MCD and are therefore potential targets for drug development.
Editor: United States: Society for Leukocyte Biology
Idioma: Inglês

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Contribution of viral and cellular cytokines to Kaposi’s sarcoma-associated herpesvirus pathogenesis

Gasperini, Paola ; Sakakibara, Shuhei ; Tosato, Giovanna

United States: Society for Leukocyte Biology

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