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Genetics of type 2 diabetes mellitus

So, W Y ; Ng, M C ; Lee, S C ; Sanke, T ; Lee, H K ; Chan, J C

Hong Kong medical journal = Xianggang yi xue za zhi, 2000-03, Vol.6 (1), p.69-76 [Periódico revisado por pares]

China: Hong Kong Academy of Medicine

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  • Título:
    Genetics of type 2 diabetes mellitus
  • Autor: So, W Y ; Ng, M C ; Lee, S C ; Sanke, T ; Lee, H K ; Chan, J C
  • Assuntos: Amyloid - genetics ; Diabetes Mellitus, Type 2 - genetics ; DNA, Mitochondrial - genetics ; Female ; Humans ; Insulin resistance ; Insulin Resistance - genetics ; Islet Amyloid Polypeptide ; Male
  • É parte de: Hong Kong medical journal = Xianggang yi xue za zhi, 2000-03, Vol.6 (1), p.69-76
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
  • Descrição: Type 2 diabetes mellitus is a heterogeneous disease that is caused by both genetic and environmental factors. Only a minority of cases of type 2 diabetes are caused by a single-gene defect, such as maturity-onset diabetes of youth (mutated MODY gene), syndrome of insulin resistance (insulin receptor defect), and maternally inherited diabetes and deafness (mitochondrial gene defect). The genetic component of the more common form of type 2 diabetes is probably complex and involves the interactions of multiple genes and environmental factors. The candidate gene approach has identified several genes that regulate insulin signalling and secretion, but their contributions to diabetes are small. Recent genome scan studies have been conducted to identify major susceptibility loci that are linked with type 2 diabetes. This information would provide new insights into the identification of novel genes and pathways that lead to this complex disease.
  • Editor: China: Hong Kong Academy of Medicine
  • Idioma: Inglês;Chinês
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