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Stem cell microencapsulation for phenotypic control, bioprocessing, and transplantation

Wilson, Jenna L. ; McDevitt, Todd C.

Biotechnology and bioengineering, 2013-03, Vol.110 (3), p.667-682 [Periódico revisado por pares]

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

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  • Título:
    Stem cell microencapsulation for phenotypic control, bioprocessing, and transplantation
  • Autor: Wilson, Jenna L. ; McDevitt, Todd C.
  • Assuntos: alginate ; Bioengineering ; bioprocessing ; Biotechnology ; Biotechnology - methods ; Cell Culture Techniques - methods ; cell therapy ; Cytological Techniques - methods ; Drug Compounding - methods ; Genotype & phenotype ; microencapsulation ; Stem Cell Transplantation - methods ; Stem cells ; Stem Cells - physiology ; Transplants & implants
  • É parte de: Biotechnology and bioengineering, 2013-03, Vol.110 (3), p.667-682
  • Notas: ark:/67375/WNG-PHKMRJXS-W
    istex:4A48A6F85D0ECA3660F303F4CDB25BE329030607
    ArticleID:BIT24802
    NSF IGERT - No. DGE 0965945
    GAANN Fellowship Department of Education - No. P200A090099
    NIH - No. EB010061
    ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-2
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  • Descrição: Cell microencapsulation has been utilized for decades as a means to shield cells from the external environment while simultaneously permitting transport of oxygen, nutrients, and secretory molecules. In designing cell therapies, donor primary cells are often difficult to obtain and expand to appropriate numbers, rendering stem cells an attractive alternative due to their capacities for self‐renewal, differentiation, and trophic factor secretion. Microencapsulation of stem cells offers several benefits, namely the creation of a defined microenvironment which can be designed to modulate stem cell phenotype, protection from hydrodynamic forces and prevention of agglomeration during expansion in suspension bioreactors, and a means to transplant cells behind a semi‐permeable barrier, allowing for molecular secretion while avoiding immune reaction. This review will provide an overview of relevant microencapsulation processes and characterization in the context of maintaining stem cell potency, directing differentiation, investigating scalable production methods, and transplanting stem cells for clinically relevant disorders. Biotechnol. Bioeng. 2013; 110: 667–682. © 2012 Wiley Periodicals, Inc. Microencapsulation of stem cells creates a defined microenvironment to modulate stem cell phenotype, protects from hydrodynamic forces and prevents agglomeration during expansion in suspension bioreactors, and is a means to transplant cells behind a semi‐permeable barrier, allowing for molecular secretion while avoiding immune reaction. This review will provide an overview of relevant microencapsulation processes and characterization in the context of maintaining stem cell potency, directing differentiation, investigating scalable production methods, and transplanting stem cells for clinically‐relevant disorders.
  • Editor: Hoboken: Wiley Subscription Services, Inc., A Wiley Company
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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