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Potential role of the ABCG2-Q141K polymorphism in type 2 diabetes

Szabó, Edit ; Kulin, Anna ; Mózner, Orsolya ; Korányi, László ; Literáti-Nagy, Botond ; Vitai, Márta ; Cserepes, Judit ; Sarkadi, Balázs ; Várady, György Singh, Kanhaiya

PloS one, 2021-12, Vol.16 (12), p.e0260957 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Potential role of the ABCG2-Q141K polymorphism in type 2 diabetes
Autor: Szabó, Edit ; Kulin, Anna ; Mózner, Orsolya ; Korányi, László ; Literáti-Nagy, Botond ; Vitai, Márta ; Cserepes, Judit ; Sarkadi, Balázs ; Várady, György
Singh, Kanhaiya
Assuntos: Aged ; Analysis ; ATP Binding Cassette Transporter, Subfamily G, Member 2 - genetics ; Biology and Life Sciences ; Blood sugar ; Case-Control Studies ; Chronic kidney failure ; Complications ; Diabetes ; Diabetes mellitus ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes Mellitus, Type 2 - genetics ; Diabetes Mellitus, Type 2 - pathology ; Disease ; Drug metabolism ; Ethylenediaminetetraacetic acid ; Extrusion ; Female ; Genetic aspects ; Genetic polymorphisms ; Genetic Predisposition to Disease ; Glucose ; Glycosylated hemoglobin ; Gout ; Health services ; Hemoglobin ; Humans ; Hypertension ; Insulin resistance ; Kidneys ; Laboratories ; Male ; Medicine and Health Sciences ; Metabolic disorders ; Metabolism ; Neoplasm Proteins - genetics ; Patients ; Pharmacokinetics ; Physical Sciences ; Physiological aspects ; Polymorphism ; Polymorphism, Single Nucleotide ; Population genetics ; Prognosis ; Proteins ; Renal failure ; Single-nucleotide polymorphism ; Type 2 diabetes ; Uric acid
É parte de: PloS one, 2021-12, Vol.16 (12), p.e0260957
Notas: Competing Interests: The authors declare no competing financial interests. J.Cs. was an employee of Cellpharma Kft., a medical biotechnology and pharmaceutical research and development company. This affiliation does not alter our adherence to all PLOS ONE policies on sharing data and materials.
Descrição: Type 2 diabetes mellitus (T2DM) is a complex metabolic disease and variations in multispecific membrane transporter functions may affect T2DM development, complications or treatment. In this work we have analyzed the potential effects of a major polymorphism, the Q141K variant of the ABCG2 transporter in T2DM. The ABCG2 protein is a multispecific xeno- and endobiotic transporter, affecting drug metabolism and playing a key role in uric acid extrusion. The ABCG2-Q141K variant, with reduced expression level and function, is present in 15-35% of individuals, depending on the genetic background of the population, and has been shown to significantly affect gout development. Several other diseases, including hypertension, chronic renal failure, and T2DM have also been reported to be associated with high serum uric acid levels, suggesting that ABCG2 may also play a role in these conditions. In this work we have compared relatively small cohorts (n = 203) of T2DM patients (n = 99) and healthy (n = 104) individuals regarding the major laboratory indicators of T2DM and determined the presence of the SNP rs2231142 (C421A), resulting the ABCG2-Q141K protein variant. We found significantly higher blood glucose and HbA1c levels in the T2DM patients carrying the ABCG2-Q141K variant. These findings may emphasize the potential metabolic role of ABCG2 in T2DM and indicate that further research should explore how prevention and treatment of this disease may be affected by the frequent polymorphism of ABCG2.
Editor: United States: Public Library of Science
Idioma: Inglês

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Potential role of the ABCG2-Q141K polymorphism in type 2 diabetes

Szabó, Edit ; Kulin, Anna ; Mózner, Orsolya ; Korányi, László ; Literáti-Nagy, Botond ; Vitai, Márta ; Cserepes, Judit ; Sarkadi, Balázs ; Várady, György Singh, Kanhaiya

United States: Public Library of Science

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