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Lipid peroxidation in bariatric candidates with nonalcoholic fatty liver disease (NAFLD) -- preliminary findings

Oliveira, Claudia P M S ; Faintuch, Joel ; Rascovski, Alessandra ; Furuya, Jr, Carlos K ; Bastos, Maria do Socorro ; Matsuda, Mitsunori ; Della Nina, Bianca I ; Yahnosi, Katia ; Abdala, Dulcineia S P ; Vezozzo, Denise C P ; Alves, Venancio A F ; Zilberstein, Bruno ; Garrido, Jr, Arthur B ; Halpern, Alfredo ; Carrilho, Flair J ; Gama-Rodrigues, J J

Obesity surgery, 2005-04, Vol.15 (4), p.502-505 [Periódico revisado por pares]

United States: Springer Nature B.V

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Título:
Lipid peroxidation in bariatric candidates with nonalcoholic fatty liver disease (NAFLD) -- preliminary findings
Autor: Oliveira, Claudia P M S ; Faintuch, Joel ; Rascovski, Alessandra ; Furuya, Jr, Carlos K ; Bastos, Maria do Socorro ; Matsuda, Mitsunori ; Della Nina, Bianca I ; Yahnosi, Katia ; Abdala, Dulcineia S P ; Vezozzo, Denise C P ; Alves, Venancio A F ; Zilberstein, Bruno ; Garrido, Jr, Arthur B ; Halpern, Alfredo ; Carrilho, Flair J ; Gama-Rodrigues, J J
Assuntos: Analysis of Variance ; Anastomosis, Roux-en-Y ; Biopsy, Needle ; Body Mass Index ; Chi-Square Distribution ; Cross-Sectional Studies ; Fatty Liver - complications ; Fatty Liver - pathology ; Female ; Follow-Up Studies ; Gastric Bypass - methods ; Humans ; Immunohistochemistry ; Intraoperative Period ; Lipid Peroxidation - physiology ; Liver cirrhosis ; Male ; Obesity, Morbid - complications ; Obesity, Morbid - diagnosis ; Obesity, Morbid - surgery ; Oxidative stress ; Oxidative Stress - physiology ; Probability ; Prospective Studies ; Risk Assessment ; Severity of Illness Index ; Statistics, Nonparametric ; Treatment Outcome
É parte de: Obesity surgery, 2005-04, Vol.15 (4), p.502-505
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Descrição: Pathogenesis of nonalcoholic fatty liver disease (NAFLD) remains incompletely known, and oxidative stress is one of the mechanisms incriminated. The aim of this study was to evaluate the role of liver oxidative stress in NAFLD affecting morbidly obese patients. 39 consecutive patients with BMI >40 kg/m2 submitted to Roux-en-Y gastric bypass were enrolled, and wedge liver biopsy was obtained during operation. Oxidative stress was measured by concentration of hydroperoxides (CEOOH) in liver tissue. Female gender was dominant (89.7%) and median age was 43.6 +/- 11.1 years. Histology showed fatty liver in 92.3%, including 43.6% with nonalcoholic steatohepatitis (NASH), 48.7% with isolated steatosis and just 7.7% with normal liver. Liver cirrhosis was present in 11.7% of those with nonalcoholic steatohepatitis. Concentration of CEOOH was increased in the liver of patients with NASH when compared to isolated steatosis and normal liver (0.26+/- 0.17, 0.20+/- 0.01 and 0.14+/- 0.00 nmol/mg protein, respectively) (P < 0.01). Liver biochemical variables were normal in 92.3% of all cases, and no difference between NASH and isolated steatosis could be demonstrated. 1) Nonalcoholic steatosis, steatohepatitis and cirrhosis were identified in substantial numbers of morbidly obese patients; 2) Concentration of hydroperoxides was increased in steatohepatitis, consistent with a pathogenetic role for oxidative stress in this condition.
Editor: United States: Springer Nature B.V
Idioma: Inglês

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Lipid peroxidation in bariatric candidates with nonalcoholic fatty liver disease (NAFLD) -- preliminary findings

United States: Springer Nature B.V

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