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The Effect of Hydrocortisone on the Kinetics of Normal Human Lymphocytes

Fauci, Anthony S. ; Dale, David C.

Blood, 1975-08, Vol.46 (2), p.235-243 [Periódico revisado por pares]

United States: Elsevier Inc

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  • Título:
    The Effect of Hydrocortisone on the Kinetics of Normal Human Lymphocytes
  • Autor: Fauci, Anthony S. ; Dale, David C.
  • Assuntos: Adult ; Bone Marrow ; Cell Movement ; Cell Separation ; Chromium Radioisotopes ; Diatrizoate ; Female ; Ficoll ; Humans ; Hydrocortisone - pharmacology ; Kinetics ; Liver - cytology ; Lung - cytology ; Lymphocytes - drug effects ; Male ; Spleen - cytology
  • É parte de: Blood, 1975-08, Vol.46 (2), p.235-243
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Lymphocyte kinetic studies employing 51chromium-labeled autologous lymphocytes were performed in nine normal volunteers in order to determine the effects of hydrocortisone administration on the recirculating versus the non recirculating intravascular lymphocyte pools. Following infusion of labeled cells, the recirculating portion of the labeled cells rapidly equilibrated with the total intravascular lymphocyte pool and the vastly larger total-body recirculating lymphocyte pool, so that by 1 hr following infusion 21.8% ± 3.2% of the labeled lymphocytes were left in the circulation. Four hundred milligrams of intravenous hydrocortisone administered 24 hr after infusion of labeled cells caused a profound but transient lymphocytopenia which was maximal at 4 hr with return of lymphocyte counts to normal by 24 hr after injection. Concomitant with the lymphocytopenia there was a dramatic increase in lymphocyte specific activity (cpm per 106 lymphocytes), while the total lymphocyte-associated radioactivity remaining in the circulation was unchanged, indicating that corticosteroid administration depleted the unlabeled recirculating cells. As the lymphocyte counts returned to normal following hydrocortisone, the specific activity also returned to normal. These studies indicated that hydrocortisone administration caused a transient lymphocytopenia by a preferential depletion of the recirculating portion of the intravascular lymphocyte pool.
  • Editor: United States: Elsevier Inc
  • Idioma: Inglês
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