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Co-receptor tropism prediction among 1045 Indian HIV-1 subtype C sequences: Therapeutic implications for India

Neogi, Ujjwal ; Prarthana, Sreenivasa B ; D'Souza, George ; Decosta, Ayesha ; Kuttiatt, Vijesh S ; Ranga, Udaykumar ; Shet, Anita

AIDS research and therapy, 2010-07, Vol.7 (1), p.24-24, Article 24 [Periódico revisado por pares]

England: BioMed Central Ltd

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  • Título:
    Co-receptor tropism prediction among 1045 Indian HIV-1 subtype C sequences: Therapeutic implications for India
  • Autor: Neogi, Ujjwal ; Prarthana, Sreenivasa B ; D'Souza, George ; Decosta, Ayesha ; Kuttiatt, Vijesh S ; Ranga, Udaykumar ; Shet, Anita
  • Assuntos: Antiviral agents ; Care and treatment ; Dosage and administration ; Health aspects ; HIV (Viruses) ; HIV infection ; Human immunodeficiency virus 1 ; Medicin och hälsovetenskap ; Physiological aspects ; Properties ; Short Report
  • É parte de: AIDS research and therapy, 2010-07, Vol.7 (1), p.24-24, Article 24
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
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    ObjectType-Feature-1
  • Descrição: Understanding co-receptor tropism of HIV-1 strains circulating in India will provide key analytical leverage for assessing the potential usefulness of newer antiretroviral drugs such as chemokine co-receptor antagonists among Indian HIV-infected populations. The objective of this study was to determine using in silico methods, HIV-1 tropism among a large number of Indian isolates both from primary clinical isolates as well as from database-derived sequences. R5-tropism was seen in 96.8% of a total of 1045 HIV-1 subtype C Indian sequences. Co-receptor prediction of 15 primary clinical isolates detected two X4-tropic strains using the C-PSSM matrix. R5-tropic HIV-1 subtype C V3 sequences were conserved to a greater extent than X4-tropic strains. X4-tropic strains were obtained from subjects who had a significantly longer time since HIV diagnosis (96.5 months) compared to R5-tropic strains (20.5 months). High prevalence of R5 tropism and greater homogeneity of the V3 sequence among HIV-1 subtype C strains in India suggests the potential benefit of CCR5 antagonists as a therapeutic option in India.
  • Editor: England: BioMed Central Ltd
  • Idioma: Inglês
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