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Polymorphic allele of human IRGM1 is associated with susceptibility to tuberculosis in African Americans

King, Katherine Y ; Lew, Justin D ; Ha, Ngan P ; Lin, Jeffery S ; Ma, Xin ; Graviss, Edward A ; Goodell, Margaret A Mokrousov, Igor

PloS one, 2011-01, Vol.6 (1), p.e16317-e16317 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Polymorphic allele of human IRGM1 is associated with susceptibility to tuberculosis in African Americans
Autor: King, Katherine Y ; Lew, Justin D ; Ha, Ngan P ; Lin, Jeffery S ; Ma, Xin ; Graviss, Edward A ; Goodell, Margaret A
Mokrousov, Igor
Assuntos: African Americans ; African Americans - genetics ; Alleles ; Apoptosis ; Autophagy ; Biology ; Confidence intervals ; Crohn Disease - genetics ; Crohn's disease ; Crohns disease ; Cytokines ; Deoxyribonucleic acid ; Disease susceptibility ; DNA ; European Continental Ancestry Group - genetics ; Gene expression ; Genes ; Genetic aspects ; Genetic Markers ; Genetic Predisposition to Disease - ethnology ; Genetic Predisposition to Disease - genetics ; GTP-Binding Proteins - genetics ; GTP-Binding Proteins - physiology ; Health risks ; Hospitals ; Humans ; Infectious diseases ; Medicine ; Minority & ethnic groups ; Mycobacterium ; Mycobacterium tuberculosis ; Phagocytosis ; Polymorphism ; Polymorphism, Single Nucleotide ; Single nucleotide polymorphisms ; Single-nucleotide polymorphism ; Tuberculosis ; Tuberculosis - ethnology ; Tuberculosis - genetics ; White people
É parte de: PloS one, 2011-01, Vol.6 (1), p.e16317-e16317
Notas: ObjectType-Article-1
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Conceived and designed the experiments: KK XM EG MG. Performed the experiments: KK JDL JSL NH. Analyzed the data: KK JSL JSL XM. Contributed reagents/materials/analysis tools: KK XM. Wrote the paper: KK XM EG MG.
Descrição: An ancestral polymorphic allele of the human autophagy-related gene IRGM1 is associated with altered gene expression and a genetic risk for Crohn's Disease (CD). We used the single nucleotide polymorphism rs10065172C/T as a marker of this polymorphic allele and genotyped 370 African American and 177 Caucasian tuberculosis (TB) cases and 180 African American and 110 Caucasian controls. Among African Americans, the TB cases were more likely to carry the CD-related T allele of rs10065172 (odds ratio of 1.54; 95% confidence interval, 1.17-2.02; P<0.01) compared to controls. Our finding suggests that this CD-related IRGM1 polymorphic allele is also associated with human susceptibility to TB disease among African Americans.
Editor: United States: Public Library of Science
Idioma: Inglês

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Polymorphic allele of human IRGM1 is associated with susceptibility to tuberculosis in African Americans

King, Katherine Y ; Lew, Justin D ; Ha, Ngan P ; Lin, Jeffery S ; Ma, Xin ; Graviss, Edward A ; Goodell, Margaret A Mokrousov, Igor

United States: Public Library of Science

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