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Epidemiological and molecular investigation of norovirus and astrovirus infections in Rio Branco, Acre, Northern Brazil: A retrospective study

Bitencurt, Evandro Leite Rodrigues ; Siqueira, Jones Anderson Monteiro ; Medeiros, Tallyta Barros ; Bandeira, Renato da Silva ; Oliveira, Darleise ; Guimarães, Ricardo José ; Soares, Luana ; Macarenhas, Joana D'Arc Pereira ; Teixeira, Dielle Monteiro ; Silva, Rita S.U. ; Loureiro, Edvaldo Carlos Brito ; Silva, Mônica Cristina ; Silva, Luciana Damascena ; Gabbay, Yvone Benchimol

Journal of medical virology, 2019-06, Vol.91 (6), p.997-1007 [Peer Reviewed Journal]

United States: Wiley Subscription Services, Inc

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Title:
Epidemiological and molecular investigation of norovirus and astrovirus infections in Rio Branco, Acre, Northern Brazil: A retrospective study
Author: Bitencurt, Evandro Leite Rodrigues ; Siqueira, Jones Anderson Monteiro ; Medeiros, Tallyta Barros ; Bandeira, Renato da Silva ; Oliveira, Darleise ; Guimarães, Ricardo José ; Soares, Luana ; Macarenhas, Joana D'Arc Pereira ; Teixeira, Dielle Monteiro ; Silva, Rita S.U. ; Loureiro, Edvaldo Carlos Brito ; Silva, Mônica Cristina ; Silva, Luciana Damascena ; Gabbay, Yvone Benchimol
Subjects: Adolescent ; Adult ; Age ; Amazon ; Astroviridae - genetics ; Astroviridae Infections - epidemiology ; Brazil ; Brazil - epidemiology ; Caliciviridae Infections - epidemiology ; Child ; Child, Preschool ; Children ; Developing countries ; diarrhea ; Epidemiology ; Feces ; Feces - virology ; Female ; Gastroenteritis ; Gastroenteritis - virology ; Genetic diversity ; Genetic Variation ; Genotype ; Genotypes ; Humans ; Infant ; Infant, Newborn ; Infections ; LDCs ; Male ; Middle Aged ; Norovirus ; Norovirus - genetics ; Nursing homes ; Outbreaks ; Phylogeny ; Prevalence ; Retrospective Studies ; RNA, Viral - genetics ; Spatial distribution ; Virology ; Viruses ; Young Adult
Is Part Of: Journal of medical virology, 2019-06, Vol.91 (6), p.997-1007
Notes: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Description: Norovirus (NoV) is a major cause of nonbacterial acute gastroenteritis (AGE) outbreaks worldwide, with infections reported in semiclosed environments, particularly in hospitals and nursing homes. Astrovirus (HAstV) is prevalent worldwide, especially in developing countries. We aimed to determine the prevalence, spatial distribution, and genetic diversity of NoV and HAstV in children under 5 years of age in Rio Branco city, Acre State, Amazon Region, Brazil. Stool samples from children with (n = 240) and without (n = 248) AGE were collected from January to December 2012 from seven neighborhoods. The overall NoV prevalence was 12.3% (60 of 488); representing 15.8% (38 of 240) of the symptomatic samples and 8.9% (22 of 248) of the controls. HAstVs infection was observed in 4.7% (23 of 488) of the samples tested, 6.2% (15 of 240) of AGE cases, and 2.4% (6 of 248) of the controls (plus two without information about feces consistency). Infections were found in all age groups with higher frequency in children less than two years of age, for both viruses. NoV was detected in all neighborhoods, with a higher concentration in the fourth (30%; 18 of 60). NoV nucleotide sequencing performed in 86.7% (52 of 60) of the positive samples showed the circulation of the strains GII.4 (57.7%; 30 of 52), GIIPe/GII.4 (19.2%; 10 of 52), GII.7, GII.Pg/GII.1, and GII.Pc (3.8%; 2 of 52 for each), GII.6 and GII.Pg (1.9%; 1 of 52 for each), and GI.3 (7.7%; 4 of 52). Three GII.4 variants were detected: Den Haag_2006b (n = 1), New Orleans_2009 (n = 1), and Sydney_2012 (n = 14). HAstV types HAstV‐1a (81.8%; 9 of 11) and HAstV‐2c (18.2%; 2 of 11) were observed in the 47.8% (11 of 23) of characterized samples. This is the first data obtained in Acre State regarding the prevalence of these viruses and provides epidemiological and molecular information for a better understanding of their role among children with and without AGE. Highlights 1‐ First data obtained in Acre State regarding the prevalence of astrovirus and norovirus. 2‐ Positivity rates by both viruses were higher in the symptomatic group than in the asymptomatic. 3‐ Evidence of two possible recombinant genotypes of norovirus.
Publisher: United States: Wiley Subscription Services, Inc
Language: English

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Epidemiological and molecular investigation of norovirus and astrovirus infections in Rio Branco, Acre, Northern Brazil: A retrospective study

United States: Wiley Subscription Services, Inc

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