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Proteomic Characterization of Antibiotic Resistance in Listeria and Production of Antimicrobial and Virulence Factors

Abril, Ana G ; Carrera, Mónica ; Böhme, Karola ; Barros-Velázquez, Jorge ; Calo-Mata, Pilar ; Sánchez-Pérez, Angeles ; Villa, Tomás G

International journal of molecular sciences, 2021-07, Vol.22 (15), p.8141 [Periódico revisado por pares]

Switzerland: MDPI AG

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Proteomic Characterization of Antibiotic Resistance in Listeria and Production of Antimicrobial and Virulence Factors
Autor: Abril, Ana G ; Carrera, Mónica ; Böhme, Karola ; Barros-Velázquez, Jorge ; Calo-Mata, Pilar ; Sánchez-Pérez, Angeles ; Villa, Tomás G
Assuntos: Anti-Bacterial Agents - pharmacology ; antibiotic production ; Antibiotic resistance ; antibiotic resistance peptides ; Antibiotics ; Antiinfectives and antibacterials ; Antimicrobial agents ; ATP-Binding Cassette Transporters - chemistry ; Bacteria ; Bacterial Proteins - chemistry ; Chromatography, Liquid - methods ; Drug development ; Drug resistance ; Drug Resistance, Multiple, Bacterial ; Enzymes ; Food contamination ; Food contamination & poisoning ; Genes, Bacterial ; Hazardous materials ; LC–ESI–MS/MS ; Liquid chromatography ; Listeria ; Listeria - classification ; Listeria - drug effects ; Listeria - genetics ; Listeria - pathogenicity ; Mass spectrometry ; Mass spectroscopy ; Multidrug resistance ; Pathogenicity ; Pathogens ; Penicillin ; Peptides ; Peptides - chemistry ; Polypeptides ; Proteins ; Proteome - chemistry ; Proteomics ; Proteomics - methods ; Resistance factors ; Scientific imaging ; Shotguns ; Spectrometry, Mass, Electrospray Ionization - methods ; Tandem Mass Spectrometry - methods ; Toxins ; Virulence ; Virulence factors ; Virulence Factors - chemistry
É parte de: International journal of molecular sciences, 2021-07, Vol.22 (15), p.8141
Descrição: Some species are important human and animal pathogens that can be found in contaminated food and produce a variety of virulence factors involved in their pathogenicity. strains exhibiting multidrug resistance are known to be progressively increasing and that is why continuous monitoring is needed. Effective therapy against pathogenic requires identification of the bacterial strain involved, as well as determining its virulence factors, such as antibiotic resistance and sensitivity. The present study describes the use of liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) to do a global shotgun proteomics characterization for pathogenic species. This method allowed the identification of a total of 2990 non-redundant peptides, representing 2727 proteins. Furthermore, 395 of the peptides correspond to proteins that play a direct role in pathogenicity; they were identified as virulence factors, toxins and anti-toxins, or associated with either antibiotics (involved in antibiotic-related compounds production or resistance) or resistance to toxic substances. The proteomic repository obtained here can be the base for further research into pathogenic species and facilitate the development of novel therapeutics for these pathogens.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Proteomic Characterization of Antibiotic Resistance in Listeria and Production of Antimicrobial and Virulence Factors

Abril, Ana G ; Carrera, Mónica ; Böhme, Karola ; Barros-Velázquez, Jorge ; Calo-Mata, Pilar ; Sánchez-Pérez, Angeles ; Villa, Tomás G

Switzerland: MDPI AG

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