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Cytogenetic Profile Predicts Prognosis of Patients With Clear Cell Renal Cell Carcinoma

KLATTE, Tobias ; NAGESH RAO, P ; DE MARTINO, Michela ; LAROCHELLE, Jeffrey ; SHUCH, Brian ; ZOMORODIAN, Nazy ; SAID, Jonathan ; KABBINAVAR, Fairooz F ; BELLDEGRUN, Arie S ; PANTUCK, Allan J

Journal of clinical oncology, 2009-02, Vol.27 (5), p.746-753 [Periódico revisado por pares]

Alexandria, VA: American Society of Clinical Oncology

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Título:
Cytogenetic Profile Predicts Prognosis of Patients With Clear Cell Renal Cell Carcinoma
Autor: KLATTE, Tobias ; NAGESH RAO, P ; DE MARTINO, Michela ; LAROCHELLE, Jeffrey ; SHUCH, Brian ; ZOMORODIAN, Nazy ; SAID, Jonathan ; KABBINAVAR, Fairooz F ; BELLDEGRUN, Arie S ; PANTUCK, Allan J
Assuntos: Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Carcinoma, Renal Cell - genetics ; Carcinoma, Renal Cell - mortality ; Chromosome Deletion ; Chromosomes, Human, Pair 14 ; Chromosomes, Human, Pair 3 ; Chromosomes, Human, Pair 4 ; Chromosomes, Human, Pair 5 ; Chromosomes, Human, Pair 6 ; Chromosomes, Human, Pair 7 ; Chromosomes, Human, Pair 8 ; Chromosomes, Human, Pair 9 ; Female ; Humans ; Karyotyping ; Kidney Neoplasms - genetics ; Kidney Neoplasms - mortality ; Kidneys ; Male ; Medical sciences ; Middle Aged ; Nephrology. Urinary tract diseases ; Prognosis ; Prospective Studies ; Sex Chromosome Aberrations ; Trisomy ; Tumors ; Tumors of the urinary system
É parte de: Journal of clinical oncology, 2009-02, Vol.27 (5), p.746-753
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: The majority of cytogenetic studies in renal cell carcinoma (RCC) have been impaired by small sample size, retrospective character, and lack of a survival end point. We prospectively studied the prognostic impact of cytogenetic abnormalities on a larger cohort of patients having up to 108 months of follow-up. Tumors of 282 patients who underwent nephrectomy for clear cell RCC were cytogenetically analyzed. Results were correlated with pathological factors and disease-specific survival. The most frequently observed cytogenetic abnormalities were loss of 3p (60%), gain of 5q (33%), loss of 14q (28%), trisomy 7 (26%), loss of 8p (20%), loss of 6q (17%), loss of 9p (16%), loss of 4p (13%), and loss of chromosome Y in men (55%). Tumors with loss of 3p presented at lower TNM stages. Loss of 4p, 9p, and 14q were all associated with higher TNM stages, higher grade, and greater tumor size. A deletion of 3p was associated with better prognosis (P = .03), while loss of 4p (P < .001), loss of 9p (P < .01), and loss of 14q (P < .01) were each associated with worse prognosis. Loss of the Y chromosome led to improved progression-free survival in metastatic patients (P = .02). In multivariate analysis, loss of 9p was retained as an independent prognostic factor. This cytogenetic study serves as a proof of principal that genetic information, such as loss of chromosome 9, can be obtained from widely available technology, and can provide additional prognostic information to standard clinicopathologic variables.
Editor: Alexandria, VA: American Society of Clinical Oncology
Idioma: Inglês

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Cytogenetic Profile Predicts Prognosis of Patients With Clear Cell Renal Cell Carcinoma

KLATTE, Tobias ; NAGESH RAO, P ; DE MARTINO, Michela ; LAROCHELLE, Jeffrey ; SHUCH, Brian ; ZOMORODIAN, Nazy ; SAID, Jonathan ; KABBINAVAR, Fairooz F ; BELLDEGRUN, Arie S ; PANTUCK, Allan J

Alexandria, VA: American Society of Clinical Oncology

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