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MAGNETIC RESONANCE STUDIES OF MEMBRANE AND MODEL MEMBRANE SYSTEMS. V. COMPARISONS OF AQUEOUS DISPERSIONS OF PURE AND MIXED PHOSPHOLIPIDS

Horwitz, A. F. ; Klein, M. P. ; Michaelson, D. M. ; Kohler, S. J.

Ann. N.Y. Acad. Sci.; (United States), 1973-12, Vol.222 (1), p.468-488 [Periódico revisado por pares]

Oxford, UK: Blackwell Publishing Ltd

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Título:
MAGNETIC RESONANCE STUDIES OF MEMBRANE AND MODEL MEMBRANE SYSTEMS. V. COMPARISONS OF AQUEOUS DISPERSIONS OF PURE AND MIXED PHOSPHOLIPIDS
Autor: Horwitz, A. F. ; Klein, M. P. ; Michaelson, D. M. ; Kohler, S. J.
Assuntos: 550200 - Biochemistry ; 550300 - Cytology ; AQUEOUS SOLUTIONS ; BASIC BIOLOGICAL SCIENCES ; BIOCHEMISTRY ; CARBOXYLIC ACIDS ; CATIONS ; CELL CONSTITUENTS ; CELL MEMBRANES ; CHARGED PARTICLES ; CHEMISTRY ; COMPARATIVE EVALUATIONS ; DISPERSIONS ; Egg Yolk ; ESTERS ; Female ; Fourier Analysis ; IONS ; LECITHINS ; LIPIDS ; MAGNETIC RESONANCE ; Magnetic Resonance Spectroscopy ; MATHEMATICAL MODELS ; Mathematics ; MEMBRANES ; Membranes, Artificial ; MIXTURES ; Models, Biological ; Models, Structural ; Molecular Conformation ; ORGANIC ACIDS ; ORGANIC COMPOUNDS ; ORGANIC PHOSPHORUS COMPOUNDS ; Palmitic Acids ; Phosphatidylcholines ; PHOSPHOLIPIDS ; RELAXATION ; RESONANCE ; Saccharomyces cerevisiae ; SOLUTIONS ; Species Specificity ; SPIN-LATTICE RELAXATION ; Ultrasonics
É parte de: Ann. N.Y. Acad. Sci.; (United States), 1973-12, Vol.222 (1), p.468-488
Notas: The work described in this paper was sponsored by the United States Atomic Energy Commission.
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United States Public Health Service Postdoctoral Fellow, 1970‐1972.
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Descrição: Phospholipid regions in cellular membranes are involved in a variety of functions, including the maintenance of permeability barriers and associations with some proteins to form functional entities. The evidence available from several physical techniques suggests that in nearly all of the membranes studied there are regions in which phospholipids are arranged in bilayers which exhibit varying degrees of mobility (or fluidity). The bilayer arrangement of phospholipids in cellular membranes is not accidental; it is a manifestation of their amphiphilic nature, and it occurs when they are isolated and dispersed into water. Since the phospholipids spontaneously form bilayer structures in water that are similar to those found in cellular membranes, and since phospholipids in lipid-water model systems are more easily studied than those in complicated membranes, it has been assumed that bilayers composed of aqueous phospholipid dispersions provide a reasonable model and convenient point of departure for studying the phospholipids in membranes. Partial solutions to questions concerning the nature of phospholipid bilayers are beginning to emerge from the results of several physical techniques. Of these techniques, NMR has been of great use in elucidating the motion of the fluid fatty acids of lecithin. In particular, T/sub 1/ measurements have provided information concerning fast processes, and T/sub 2/ measurements have provided information about relatively slower processes. This paper discussed briefly some relevant topics in relaxation theory, review work on both sonicated and unsonicated lecithins and the dynamic model that is proposed to explain the relaxation data, report some effects of altered fatty acid composition on the NMR parameters, report results concerning the interactions of cations with two phospholipids; phosphatidylcholine which is zwitterionic and phosphatidylglycerol (PG) which is anionic, and, finally, the behavior of aqueous dispersions of PC--PG mixtures.
Editor: Oxford, UK: Blackwell Publishing Ltd
Idioma: Inglês

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MAGNETIC RESONANCE STUDIES OF MEMBRANE AND MODEL MEMBRANE SYSTEMS. V. COMPARISONS OF AQUEOUS DISPERSIONS OF PURE AND MIXED PHOSPHOLIPIDS

Horwitz, A. F. ; Klein, M. P. ; Michaelson, D. M. ; Kohler, S. J.

Oxford, UK: Blackwell Publishing Ltd

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