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Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma

SUNG, Wing-Kin ; HANCHENG ZHENG ; MULAWADI, Fabianus H ; WONG, Kwong F ; LIU, Angela M ; POON, Ronnie T ; SHEUNG TAT FAN ; CHAN, Kwong L ; ZHUOLIN GONG ; YUJIE HU ; ZHAO LIN ; GUAN WANG ; SHUYU LI ; QINGHUI ZHANG ; BARBER, Thomas D ; CHOU, Wen-Chi ; AGGARWAL, Amit ; KE HAO ; WEI ZHOU ; CHUNSHENG ZHANG ; HARDWICK, James ; BUSER, Carolyn ; JIANGCHUN XU ; RONGHUA CHEN ; ZHENGYAN KAN ; HONGYUE DAI ; MAO MAO ; REINHARD, Christoph ; JUN WANG ; LUK, John M ; XIAO LIU ; YINGRUI LI ; LEE, Nikki P ; LEE, Wah H ; ARIYARATNE, Pramila N ; TENNAKOON, Chandana

Nature genetics, 2012-07, Vol.44 (7), p.765-769 [Periódico revisado por pares]

New York, NY: Nature Publishing Group

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Título:
Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma
Autor: SUNG, Wing-Kin ; HANCHENG ZHENG ; MULAWADI, Fabianus H ; WONG, Kwong F ; LIU, Angela M ; POON, Ronnie T ; SHEUNG TAT FAN ; CHAN, Kwong L ; ZHUOLIN GONG ; YUJIE HU ; ZHAO LIN ; GUAN WANG ; SHUYU LI ; QINGHUI ZHANG ; BARBER, Thomas D ; CHOU, Wen-Chi ; AGGARWAL, Amit ; KE HAO ; WEI ZHOU ; CHUNSHENG ZHANG ; HARDWICK, James ; BUSER, Carolyn ; JIANGCHUN XU ; RONGHUA CHEN ; ZHENGYAN KAN ; HONGYUE DAI ; MAO MAO ; REINHARD, Christoph ; JUN WANG ; LUK, John M ; XIAO LIU ; YINGRUI LI ; LEE, Nikki P ; LEE, Wah H ; ARIYARATNE, Pramila N ; TENNAKOON, Chandana
Assuntos: Base Sequence ; Biological and medical sciences ; Carcinoma, Hepatocellular - genetics ; Carcinoma, Hepatocellular - virology ; Causes of ; Chromosomal Instability - genetics ; Cyclin E - genetics ; DNA Copy Number Variations - genetics ; DNA, Viral - genetics ; DNA-Binding Proteins - genetics ; Female ; Fundamental and applied biological sciences. Psychology ; Gastroenterology. Liver. Pancreas. Abdomen ; Gene expression ; Genetic aspects ; Genetics ; Genetics of eukaryotes. Biological and molecular evolution ; Genomes ; Health aspects ; Hepatitis B virus ; Hepatitis B virus - genetics ; Hepatoma ; Humans ; Liver cancer ; Liver Neoplasms - genetics ; Liver Neoplasms - virology ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Middle Aged ; Molecular Sequence Data ; Oncogene Proteins - genetics ; RNA, Viral - genetics ; Studies ; Survival Rate ; Telomerase - genetics ; Tumors ; Virus Integration - genetics
É parte de: Nature genetics, 2012-07, Vol.44 (7), p.765-769
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: To survey hepatitis B virus (HBV) integration in liver cancer genomes, we conducted massively parallel sequencing of 81 HBV-positive and 7 HBV-negative hepatocellular carcinomas (HCCs) and adjacent normal tissues. We found that HBV integration is observed more frequently in the tumors (86.4%) than in adjacent liver tissues (30.7%). Copy-number variations (CNVs) were significantly increased at HBV breakpoint locations where chromosomal instability was likely induced. Approximately 40% of HBV breakpoints within the HBV genome were located within a 1,800-bp region where the viral enhancer, X gene and core gene are located. We also identified recurrent HBV integration events (in ≥ 4 HCCs) that were validated by RNA sequencing (RNA-seq) and Sanger sequencing at the known and putative cancer-related TERT, MLL4 and CCNE1 genes, which showed upregulated gene expression in tumor versus normal tissue. We also report evidence that suggests that the number of HBV integrations is associated with patient survival.
Editor: New York, NY: Nature Publishing Group
Idioma: Inglês

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Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma

New York, NY: Nature Publishing Group

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