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Relationship between cyclooxygenase-2 and nitric oxide synthase-2 in rat cortex after stress

Madrigal, José L. M. ; García-Bueno, Borja ; Moro, María A. ; Lizasoain, Ignacio ; Lorenzo, Pedro ; Leza, Juan C.

The European journal of neuroscience, 2003-09, Vol.18 (6), p.1701-1705 [Revista revisada por pares]

Oxford, UK: Blackwell Science, Ltd

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Título:
Relationship between cyclooxygenase-2 and nitric oxide synthase-2 in rat cortex after stress
Autor: Madrigal, José L. M. ; García-Bueno, Borja ; Moro, María A. ; Lizasoain, Ignacio ; Lorenzo, Pedro ; Leza, Juan C.
Materias: Amidines - pharmacology ; Animals ; Benzylamines - pharmacology ; Blotting, Western ; Brain Chemistry - drug effects ; Cerebral Cortex - drug effects ; Cerebral Cortex - enzymology ; Cerebral Cortex - metabolism ; Corticosterone - blood ; Cyclooxygenase 2 ; Cyclooxygenase 2 Inhibitors ; Cyclooxygenase Inhibitors - pharmacology ; Enzyme Inhibitors - pharmacology ; Isoenzymes - metabolism ; Male ; neurodegeneration ; Nitric Oxide Synthase - metabolism ; Nitric Oxide Synthase Type II ; Nitrobenzenes - pharmacology ; oxidative status ; Prostaglandin-Endoperoxide Synthases - metabolism ; Rats ; Rats, Wistar ; stress ; Stress, Physiological - enzymology ; Stress, Physiological - metabolism ; Sulfonamides - pharmacology ; Time Factors
Es parte de: The European journal of neuroscience, 2003-09, Vol.18 (6), p.1701-1705
Notas: istex:B9D1C9FFCFC5446891EC70B58925F405900FCE90
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ArticleID:EJN2888
ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descripción: Many studies have focused on the relationships between distinct enzymatic sources of oxidative mediators. Recently, we have shown that cyclooxygenase‐2 (COX‐2) and inducible nitric oxide synthase (NOS‐2) isoforms are up‐regulated and account for oxidative damage in brain after stress. To assess the time course of these events, we have used adult male Wistar rats, some of which were immobilized for 6 h. Whereas pretreatment with the specific COX‐2 inhibitor NS‐398 (5 mg/kg i.p.) decreased Ca2+‐independent NOS activity after 6 h of stress, pretreatment with the specific NOS‐2 inhibitor 1400 W (4 mg/kg i.p.) did not decrease prostaglandin E2 (PGE2) accumulation induced by stress after 6 h. The observed effects of NS‐398 and 1400 W were independent of the general response to stress – neither drug modified stress‐induced corticosterone response – which might indicate a possible adaptive role for COX‐2 and NOS‐2 pathways in this situation. These findings are discussed as possible therapeutic targets in the context of neuropsychiatric disorders related to stress.
Editor: Oxford, UK: Blackwell Science, Ltd
Idioma: Inglés

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Relationship between cyclooxygenase-2 and nitric oxide synthase-2 in rat cortex after stress

Madrigal, José L. M. ; García-Bueno, Borja ; Moro, María A. ; Lizasoain, Ignacio ; Lorenzo, Pedro ; Leza, Juan C.

Oxford, UK: Blackwell Science, Ltd

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