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Impaired glucose tolerance is associated with increased serum concentrations of interleukin 6 and co-regulated acute-phase proteins but not TNF-α or its receptors

MÜLLER, S ; MARTIN, S ; KOENIG, W ; HANIFI-MOGHADDAM, P ; RATHMANN, W ; HAASTERT, B ; GIANI, G ; ILLIG, T ; THORAND, B ; KOLB, H

Diabetologia, 2002-06, Vol.45 (6), p.805-812 [Periódico revisado por pares]

Berlin: Springer

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Título:
Impaired glucose tolerance is associated with increased serum concentrations of interleukin 6 and co-regulated acute-phase proteins but not TNF-α or its receptors
Autor: MÜLLER, S ; MARTIN, S ; KOENIG, W ; HANIFI-MOGHADDAM, P ; RATHMANN, W ; HAASTERT, B ; GIANI, G ; ILLIG, T ; THORAND, B ; KOLB, H
Assuntos: Acute-Phase Proteins - metabolism ; Aged ; Biological and medical sciences ; Blood Glucose - metabolism ; Blood Pressure ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - immunology ; Diabetes Mellitus, Type 2 - physiopathology ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Glucose Intolerance - blood ; Glucose Intolerance - immunology ; Glucose Intolerance - physiopathology ; Glucose Tolerance Test ; Humans ; Interleukin-6 - blood ; Lipids - blood ; Male ; Medical sciences ; Receptors, Tumor Necrosis Factor - blood ; Reference Values ; Tumor Necrosis Factor-alpha - metabolism
É parte de: Diabetologia, 2002-06, Vol.45 (6), p.805-812
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: A population-based sample was studied to define immune abnormalities in individuals at risk of Type II (non-insulin-dependent) diabetes mellitus because of impaired glucose tolerance. A total of 1653 individuals aged 55 to 74 years participated in a population based survey in Southern Germany (KORA Survey 2000). Those without a history of diabetes were subjected to an OGTT. Randomly selected subjects with IGT ( n=80) were compared with non-diabetic control subjects ( n=77) and patients with Type II diabetes ( n=152) of the same population-based sample after matching for age and sex. Immune parameters were analysed in serum with rigidly evaluated ELISA. Serum pro-inflammatory cytokine interleukin 6 (IL-6) concentrations were higher in subjects with IGT and Type II diabetes than in the control subjects (median 1.8 and 2.5 vs 0.8 pg/ml, p<0.0001). Soluble IL-6 receptors potentiate IL-6 bioactivity and their concentrations were mildly increased in Type II diabetes ( p<0.05). These immune changes seem relevant because IL-6 dependent acute-phase proteins C-reactive protein, serum amyloid A protein and fibrinogen were also increased in IGT and Type II diabetes. Circulating concentrations of TNF-alpha and its two receptors sTNF-R60 and sTNF-R80 were not increased in IGT subjects compared with the control subjects. Our study shows systemic up-regulation of selected inflammatory mediators in patients with Type II diabetes and IGT. The pattern observed is non-random and fits with an IL-6 associated rather than TNF-alpha associated response.
Editor: Berlin: Springer
Idioma: Inglês

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Impaired glucose tolerance is associated with increased serum concentrations of interleukin 6 and co-regulated acute-phase proteins but not TNF-α or its receptors

MÜLLER, S ; MARTIN, S ; KOENIG, W ; HANIFI-MOGHADDAM, P ; RATHMANN, W ; HAASTERT, B ; GIANI, G ; ILLIG, T ; THORAND, B ; KOLB, H

Berlin: Springer

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