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Evaluation of the development of secondary tumor risks using radiotherapy treatment in patients with COVID-19

Weber, Raissa Renata Dos Santos

Biblioteca Digital de Teses e Dissertações da USP; Universidade de São Paulo; Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto 2023-06-20

Acesso online. A biblioteca também possui exemplares impressos.

  • Título:
    Evaluation of the development of secondary tumor risks using radiotherapy treatment in patients with COVID-19
  • Autor: Weber, Raissa Renata Dos Santos
  • Orientador: Pavoni, Juliana Fernandes
  • Assuntos: Covid-19; Epidemiologia; Radiação Ionizante; Risco De Indução De Câncer; Covid-19; Epidemiology; Ionizing Radiation; Risk Of Induced-Cancer
  • Notas: Dissertação (Mestrado)
  • Descrição: SARS-CoV-2, most well-known as COVID-19, is an enveloped and single-stranded RNA virus larger than any RNA virus. Because it is highly contagious, there is no effective specific treatment for this disease, especially severe lung inflammation. In addition, there are limitations of medications, some of which are not recommended. Thus, clinical trials emerged with the premise of using low-dose radiation treatment to treat patients with pneumonia due to COVID-19. In this work, we investigated the risks of induced cancer and the effectiveness of low-dose radiation treatment in patients with pneumonia due to COVID-19. For this, mathematical models from epidemiological studies for ionizing radiation were used, and the clinical trial results were analyzed. Data were characterized by mathematical models from the mean doses collected using a virtual simulation for radiotherapy planning. The risks of induced cancer were estimated based on the doses used in clinical trials. A systematic review was performed regarding clinical trials. It was verified that each mathematical model has an individual characterization for estimating the risk of induced cancer and inferring that the risks are potential for incidence and mortality due to induced cancer exposure to ionizing radiation. The results of clinical trials were not favorable, as a significant number of patients succumbed even after treatment with low doses of ionizing radiation, showing the ineffectiveness of the practice. Therefore, considering the limitations of epidemiological studies in formulating mathematical models and the low sampling of data from clinical trials, treatment with low-dose ionizing radiation for patients with pneumonia due to COVID-19 is not justifiable.
  • DOI: 10.11606/D.59.2023.tde-17072023-075750
  • Editor: Biblioteca Digital de Teses e Dissertações da USP; Universidade de São Paulo; Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto
  • Data de criação/publicação: 2023-06-20
  • Formato: Adobe PDF
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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