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Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response

Spencer, Christine N ; McQuade, Jennifer L ; Gopalakrishnan, Vancheswaran ; McCulloch, John A ; Vetizou, Marie ; Cogdill, Alexandria P ; Khan, Md A Wadud ; Zhang, Xiaotao ; White, Michael G ; Peterson, Christine B ; Wong, Matthew C ; Morad, Golnaz ; Rodgers, Theresa ; Badger, Jonathan H ; Helmink, Beth A ; Andrews, Miles C ; Rodrigues, Richard R ; Morgun, Andrey ; Kim, Young S ; Roszik, Jason ; Hoffman, Kristi L ; Zheng, Jiali ; Zhou, Yifan ; Medik, Yusra B ; Kahn, Laura M ; Johnson, Sarah ; Hudgens, Courtney W ; Wani, Khalida ; Gaudreau, Pierre-Olivier ; Harris, Angela L ; Jamal, Mohamed A ; Baruch, Erez N ; Perez-Guijarro, Eva ; Day, Chi-Ping ; Merlino, Glenn ; Pazdrak, Barbara ; Lochmann, Brooke S ; Szczepaniak-Sloane, Robert A ; Arora, Reetakshi ; Anderson, Jaime ; Zobniw, Chrystia M ; Posada, Eliza ; Sirmans, Elizabeth ; Simon, Julie ; Haydu, Lauren E ; Burton, Elizabeth M ; Wang, Linghua ; Dang, Minghao ; Clise-Dwyer, Karen ; Schneider, Sarah ; Chapman, Thomas ; Anang, Nana-Ama A S ; Duncan, Sheila ; Toker, Joseph ; Malke, Jared C ; Glitza, Isabella C ; Amaria, Rodabe N ; Tawbi, Hussein A ; Diab, Adi ; Wong, Michael K ; Patel, Sapna P ; Woodman, Scott E ; Davies, Michael A ; Ross, Merrick I ; Gershenwald, Jeffrey E ; Lee, Jeffrey E ; Hwu, Patrick ; Jensen, Vanessa ; Samuels, Yardena ; Straussman, Ravid ; Ajami, Nadim J ; Nelson, Kelly C ; Nezi, Luigi ; Petrosino, Joseph F ; Futreal, P Andrew ; Lazar, Alexander J ; Hu, Jianhua ; Jenq, Robert R ; Tetzlaff, Michael T ; Yan, Yan ; Garrett, Wendy S ; Huttenhower, Curtis ; Sharma, Padmanee ; Watowich, Stephanie S ; Allison, James P ; Cohen, Lorenzo ; Trinchieri, Giorgio ; Daniel, Carrie R ; Wargo, Jennifer A

Science (American Association for the Advancement of Science), 2021-12, Vol.374 (6575), p.1632-1640 [Periódico revisado por pares]

United States: The American Association for the Advancement of Science

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Título:
Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response
Autor: Spencer, Christine N ; McQuade, Jennifer L ; Gopalakrishnan, Vancheswaran ; McCulloch, John A ; Vetizou, Marie ; Cogdill, Alexandria P ; Khan, Md A Wadud ; Zhang, Xiaotao ; White, Michael G ; Peterson, Christine B ; Wong, Matthew C ; Morad, Golnaz ; Rodgers, Theresa ; Badger, Jonathan H ; Helmink, Beth A ; Andrews, Miles C ; Rodrigues, Richard R ; Morgun, Andrey ; Kim, Young S ; Roszik, Jason ; Hoffman, Kristi L ; Zheng, Jiali ; Zhou, Yifan ; Medik, Yusra B ; Kahn, Laura M ; Johnson, Sarah ; Hudgens, Courtney W ; Wani, Khalida ; Gaudreau, Pierre-Olivier ; Harris, Angela L ; Jamal, Mohamed A ; Baruch, Erez N ; Perez-Guijarro, Eva ; Day, Chi-Ping ; Merlino, Glenn ; Pazdrak, Barbara ; Lochmann, Brooke S ; Szczepaniak-Sloane, Robert A ; Arora, Reetakshi ; Anderson, Jaime ; Zobniw, Chrystia M ; Posada, Eliza ; Sirmans, Elizabeth ; Simon, Julie ; Haydu, Lauren E ; Burton, Elizabeth M ; Wang, Linghua ; Dang, Minghao ; Clise-Dwyer, Karen ; Schneider, Sarah ; Chapman, Thomas ; Anang, Nana-Ama A S ; Duncan, Sheila ; Toker, Joseph ; Malke, Jared C ; Glitza, Isabella C ; Amaria, Rodabe N ; Tawbi, Hussein A ; Diab, Adi ; Wong, Michael K ; Patel, Sapna P ; Woodman, Scott E ; Davies, Michael A ; Ross, Merrick I ; Gershenwald, Jeffrey E ; Lee, Jeffrey E ; Hwu, Patrick ; Jensen, Vanessa ; Samuels, Yardena ; Straussman, Ravid ; Ajami, Nadim J ; Nelson, Kelly C ; Nezi, Luigi ; Petrosino, Joseph F ; Futreal, P Andrew ; Lazar, Alexander J ; Hu, Jianhua ; Jenq, Robert R ; Tetzlaff, Michael T ; Yan, Yan ; Garrett, Wendy S ; Huttenhower, Curtis ; Sharma, Padmanee ; Watowich, Stephanie S ; Allison, James P ; Cohen, Lorenzo ; Trinchieri, Giorgio ; Daniel, Carrie R ; Wargo, Jennifer A
Assuntos: Animals ; Apoptosis ; Cancer ; Cell death ; Cohort Studies ; Consumption ; Cytotoxicity ; Diet ; Dietary Fiber ; Dietary intake ; Dietary supplements ; Digestive system ; Fatty Acids, Volatile - analysis ; Fecal Microbiota Transplantation ; Fecal microflora ; Feces - chemistry ; Feces - microbiology ; Female ; Food intake ; Gastrointestinal Microbiome ; Humans ; Immune checkpoint ; Immune Checkpoint Inhibitors - therapeutic use ; Immune response ; Immune system ; Immunotherapy ; Interferon ; Intestinal microflora ; Lymphocytes ; Lymphocytes T ; Male ; Melanoma ; Melanoma - immunology ; Melanoma - microbiology ; Melanoma - therapy ; Melanoma, Experimental - immunology ; Melanoma, Experimental - microbiology ; Melanoma, Experimental - therapy ; Mice ; Mice, Inbred C57BL ; Microbiomes ; Microbiota ; Nutrient deficiency ; Patients ; PD-1 protein ; Probiotics ; Progression-Free Survival ; T-Lymphocytes ; Tumor microenvironment ; γ-Interferon
É parte de: Science (American Association for the Advancement of Science), 2021-12, Vol.374 (6575), p.1632-1640
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These authors contributed equally to this work.
Present address: AstraZeneca, Gaithersburg, MD 20878, USA.
Present address: Department of Epidemiology and Biostatistics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Present address: Department of Informatics, Parker Institute for Cancer Immunotherapy, San Francisco, CA 94129, USA.
Present address: Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
Author contributions: Project conceptualization: C.N.S., J.L.M., C.H., M.V., N.J.A., G.T., L.C., W.S.G., C.R.D., S.S.W., J.A.W., M.I.R., Y.S., and M.A.W.K. Methodology: C.N.S., J.L.M., N.J.A., V.G., C.H., M.V., J.C.M., G.T., L.C., C.R.D., J.A.W., K.L.H., J.A.M., C.B.P., J.H., A.J.L., and M.A.W.K. Software: C.N.S., V.G., M.A.W.K., J.Z., X.Z., K.L.H., J.F.P., J.R., N.J.A., M.C.W., L.E.H., Y.Y., C.H., J.A.M., J.H.B., R.R.R., and A.M. Validation: M.V., J.A.M., C.N.S., V.G., M.A.W.K., J.Z., X.Z., A.P.C., S.S.W., Y.Z., Y.B.M., S.J., L.N., S.J., and H.A.T. Formal analysis: C.N.S., V.G., A.P.C., M.A.W.K., J.Z., X.Z., K.L.H., J.R., N.J.A., Y.Y., C.H., J.A.M., R.R.R., A.M., C.B.P., J.H., C.R.D., L.W., L.N., and N.-A.A.S.A. Investigation: C.N.S., J.L.M., B.A.H., A.P.C., P.-O.G., C.W.H., K.W., S.S.W., Y.Z., Y.B.M., M.V., Y.S.K., E.P.-G., I.C.G., R.N.A., H.A.T., A.D., M.K.W., S.P.P., S.E.W., M.A.D., M.I.R., J.E.G., J.E.L., P.H., V.J., K.C.N., A.J.L., M.T.T., L.M.K., A.L.H., M.A.J., E.N.B., B.P., B.S.L., K.C.-D., T.C., S.S., N.-A.A.S.A., J.T., V.J., C.M.Z., M.A.W.K., and J.A.W. Resources: J.A.W., J.P.A., P.S., S.S.W., R.R.J., C.H., G.T., J.F.P., P.A.F., G.Me., E.P.-G., C.-P.D., A.J.L., B.S.L., and H.A.T. Data curation: M.W., N.J.A., J.A.M., R.R.R., A.M., C.N.S., J.L.M., C.R.D., E.S., E.P., L.E.H., J.C.M., T.R., E.N.B., R.A.S.-S., J.A., C.M.Z., L.W., M.C.W., M.C.A., N.-A.A.S.A., and B.S.L. Writing - original draft: C.N.S., J.L.M., V.G., J.A.M., M.V., A.P.C., M.A.W.K., N.J.A., L.N., S.S.W., L.C., G.T., C.R.D., J.A.W., J.H., J.P.A., and P.S. Writing - review and editing: C.N.S., J.L.M., V.G., J.A.M., M.V., A.P.C., M.A.W.K., X.Z., M.G.W., C.B.P., M.C.W., G.Me., T.R., J.H.B., B.A.H., M.C.A., R.R.R., A.M., Y.S.K., J.R., K.L.H., J.Z., Y.Z., Y.B.M., L.M.K., S.J., C.W.H., K.W., P.-O.G., A.L.H., M.A.J., E.N.B., E.P.-G., C.-P.D., G.Mo., B.P., B.S.L., R.A.S.-S., R.A., J.A., C.M.Z., E.P., E.S., J.S., L.E.H., E.M.B., L.W., M.D., K.C.-D., S.S., T.C., N.-A.A.S.A., S.D., J.T., J.C.M., I.C.G., R.N.A., H.A.T., A.D., M.K.W., S.P.P., S.E.W., M.A.D., M.I.R., J.E.G., J.E.L., P.H., V.J., Y.S., R.S., N.J.A., K.C.N., L.N., J.F.P., P.A.F., A.J.L., J.H., R.R.J., R.R.R., Y.Y., W.S.G., C.H., P.S., S.S.W., J.P.A., L.C., G.T., C.R.D., and J.A.W. Visualization: C.N.S., J.L.M., V.G., J.A.M., M.V., A.P.C., M.A.W.K., X.Z., N.J.A., R.R.R., A.M., C.B.P., J.H., C.R.D., J.A.W., G.T., Y.Y., C.H., K.C.-D., and M.I.R. Supervision: C.N.S., J.L.M., V.G., L.C., M.V., G.T., C.H., C.R.D., J.A.W., and P.A.F. Project administration: C.N.S., J.L.M., M.G.W., S.D., E.M.B., J.S., L.E.H., C.R.D., J.A.W., M.V., G.T., and G.Me. Funding acquisition: J.L.M., C.R.D., L.C., J.A.W., E.M.B., G.T., M.A.D., C.H., and Y.S.
Present address: Immunai, New York, NY 10013, USA.
Present address: Administration, Moffitt Cancer Center, Tampa, FL 33612, USA.
Descrição: Gut bacteria modulate the response to immune checkpoint blockade (ICB) treatment in cancer, but the effect of diet and supplements on this interaction is not well studied. We assessed fecal microbiota profiles, dietary habits, and commercially available probiotic supplement use in melanoma patients and performed parallel preclinical studies. Higher dietary fiber was associated with significantly improved progression-free survival in 128 patients on ICB, with the most pronounced benefit observed in patients with sufficient dietary fiber intake and no probiotic use. Findings were recapitulated in preclinical models, which demonstrated impaired treatment response to anti–programmed cell death 1 (anti–PD-1)–based therapy in mice receiving a low-fiber diet or probiotics, with a lower frequency of interferon-γ–positive cytotoxic T cells in the tumor microenvironment. Together, these data have clinical implications for patients receiving ICB for cancer.
Editor: United States: The American Association for the Advancement of Science
Idioma: Inglês

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Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response

United States: The American Association for the Advancement of Science

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