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Endothelin stimulates c-fos and c-myc expression and proliferation of vascular smooth muscle cells

Komuro, Issei ; Kurihara, Hiroki ; Sugiyama, Takao ; Takaku, Fumimaro ; Yazaki, Yoshio

FEBS letters, 1988-10, Vol.238 (2), p.249-252 [Periódico revisado por pares]

Amsterdam: Elsevier B.V

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Título:
Endothelin stimulates c-fos and c-myc expression and proliferation of vascular smooth muscle cells
Autor: Komuro, Issei ; Kurihara, Hiroki ; Sugiyama, Takao ; Takaku, Fumimaro ; Yazaki, Yoshio
Assuntos: [Ca2+]i, intracellular calcium ; Animals ; Atherosclerosis ; Biological and medical sciences ; c-fos gene ; c-myc gene ; Ca 2 ; Ca2 ; Calcium - metabolism ; Cell Division ; DMEM, Dulbecco's modified Eagle's medium ; DNA - biosynthesis ; EC, endothelial cell ; EDT, endothelin ; EGF, epidermal growth factor ; Endothelin ; Endothelins ; Endothelium, Vascular - analysis ; FCS, fetal calf serum ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation ; Genes. Genome ; Kinetics ; Molecular and cellular biology ; Molecular genetics ; Muscle, Smooth, Vascular - cytology ; Muscle, Smooth, Vascular - metabolism ; PBS, phosphate-buffered saline ; PDGF, platelet-derived growth factor ; Peptides - pharmacology ; Proto-Oncogene Proteins - genetics ; Proto-Oncogene Proteins c-fos ; Proto-Oncogene Proteins c-myc ; Rats ; RNA, Messenger - biosynthesis ; Vascular smooth muscle ; VSMC, vascular smooth muscle cell
É parte de: FEBS letters, 1988-10, Vol.238 (2), p.249-252
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
Descrição: Recently, a potent vasoconstrictor peptide, endothelin (EDT), was isolated from vascular endothelial cells. We examined its effect on rat vascular smooth muscle cells (VSMCs). EDT induced the elevation of intracellular calcium, which was dependent on extracellular calcium and inhibited by a calcium-channel antagonist in a competitive manner. EDT caused a rapid and transient increase in the c-fos and c-myc mRNA levels and stimulated the DNA synthesis of VSMCs in a dose-dependent manner. This effect of EDT on the proliferation of VSMCs might be related to the development of atherosclerosis.
Editor: Amsterdam: Elsevier B.V
Idioma: Inglês

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Endothelin stimulates c-fos and c-myc expression and proliferation of vascular smooth muscle cells

Komuro, Issei ; Kurihara, Hiroki ; Sugiyama, Takao ; Takaku, Fumimaro ; Yazaki, Yoshio

Amsterdam: Elsevier B.V

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