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Selective dependence on IL-7 for antigen-specific CD8 T cell responses during airway influenza infection

Sheikh, Abdalla ; Jackson, Jennie ; Shim, Hanjoo Brian ; Yau, Clement ; Seo, Jung Hee ; Abraham, Ninan

Scientific reports, 2022-01, Vol.12 (1), p.135-135, Article 135 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
Selective dependence on IL-7 for antigen-specific CD8 T cell responses during airway influenza infection
Autor: Sheikh, Abdalla ; Jackson, Jennie ; Shim, Hanjoo Brian ; Yau, Clement ; Seo, Jung Hee ; Abraham, Ninan
Assuntos: A549 Cells ; Alphainfluenzavirus - immunology ; Alphainfluenzavirus - pathogenicity ; Animals ; CD8 antigen ; CD8-Positive T-Lymphocytes - immunology ; CD8-Positive T-Lymphocytes - metabolism ; Cell survival ; Cytokines ; Degranulation ; Dendritic Cells - immunology ; Dendritic Cells - metabolism ; Dendritic Cells - virology ; Disease Models, Animal ; Female ; Host-Pathogen Interactions ; Humans ; Infections ; Influenza ; Interleukin 7 ; Interleukin-7 - genetics ; Interleukin-7 - metabolism ; Interleukin-7 Receptor alpha Subunit - genetics ; Interleukin-7 Receptor alpha Subunit - metabolism ; Lung - immunology ; Lung - metabolism ; Lung - virology ; Lymph nodes ; Lymph Nodes - immunology ; Lymph Nodes - metabolism ; Lymph Nodes - virology ; Lymphatic system ; Lymphocytes ; Lymphocytes T ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Mutation ; Orthomyxoviridae Infections - genetics ; Orthomyxoviridae Infections - immunology ; Orthomyxoviridae Infections - metabolism ; Orthomyxoviridae Infections - virology ; Programmed Cell Death 1 Receptor - genetics ; Programmed Cell Death 1 Receptor - metabolism ; Respiratory diseases ; Signal Transduction ; Viral infections
É parte de: Scientific reports, 2022-01, Vol.12 (1), p.135-135, Article 135
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Interleukin-7 (IL-7) is a cytokine known for its importance in T cell development and survival. How IL-7 shapes CD8 T cell responses during an acute viral infection is less understood. We had previously shown that IL-7 signaling deficient mice have reduced accumulation of influenza-specific CD8 T cells following influenza infection. We sought to determine whether IL-7 affects early CD8 T cell expansion in the mediastinal lymph node and effector function in the lungs. Using IL-7Rα signaling deficient mice, we show that IL-7 is required for a normal sized mediastinal lymph node and the early clonal expansion of influenza-specific CD8 T cells therein. We show that IL-7 plays a cell-intrinsic role in the accumulation of NP and PA -specific CD8 T cells in the lymph node. We also found that IL-7 shapes terminal differentiation, degranulation and cytokine production to a greater extent in PA -specific than NP -specific CD8 T cells. We further demonstrate that IL-7 is induced in the lung tissue by viral infection and we characterize multiple cellular sources that contribute to IL-7 production. Our findings on IL-7 and its effects on lower respiratory diseases will be important for expanding the utility of therapeutics that are currently available.
Editor: England: Nature Publishing Group
Idioma: Inglês

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Selective dependence on IL-7 for antigen-specific CD8 T cell responses during airway influenza infection

Sheikh, Abdalla ; Jackson, Jennie ; Shim, Hanjoo Brian ; Yau, Clement ; Seo, Jung Hee ; Abraham, Ninan

England: Nature Publishing Group

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