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Mitochondria permeability transition-dependent tert-butyl hydroperoxide-induced apoptosis in hepatoma HepG2 cells

Piret, Jean-Pascal ; Arnould, Thierry ; Fuks, Bruno ; Chatelain, Pierre ; Remacle, José ; Michiels, Carine

Biochemical pharmacology, 2004-02, Vol.67 (4), p.611-620 [Periódico revisado por pares]

New York, NY: Elsevier Inc

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Título:
Mitochondria permeability transition-dependent tert-butyl hydroperoxide-induced apoptosis in hepatoma HepG2 cells
Autor: Piret, Jean-Pascal ; Arnould, Thierry ; Fuks, Bruno ; Chatelain, Pierre ; Remacle, José ; Michiels, Carine
Assuntos: Apoptosis ; Biological and medical sciences ; Caspase ; Caspases - metabolism ; Cytochromes c - metabolism ; DNA fragmentation ; DNA Fragmentation - drug effects ; Enzyme Activation - drug effects ; Humans ; Medical sciences ; Mitochondria ; Mitochondria - drug effects ; Mitochondria - physiology ; Permeability - drug effects ; Permeability transition pore ; Pharmacology. Drug treatments ; Signal Transduction - drug effects ; tert-Butylhydroperoxide - pharmacology ; Tumor Cells, Cultured
É parte de: Biochemical pharmacology, 2004-02, Vol.67 (4), p.611-620
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Tert-butyl hydroperoxide ( t-BHP) has been demonstrated to induce apoptosis in hepatoma cell line HepG2, but poor data were available on the signaling pathway initiated by t-BHP. In this work, we studied in details the apoptotic pathways induced in HepG2 cells by t-BHP. DNA fragmentation, activation of caspases and cytochrome c release were demonstrated. Permeability transition pore inhibitors prevented the DNA fragmentation and caspase activation induced by t-BHP. In addition, changes in the mitochondrial membrane potential were detected: hyperpolarization preceded loss of membrane potential. It also preceded caspase activation which occurred before the induction of DNA fragmentation. Taken together, these results emphasize the central role played by mitochondria in the initiation of apoptosis in HepG2 cells exposed to oxidant agents.
Editor: New York, NY: Elsevier Inc
Idioma: Inglês

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Mitochondria permeability transition-dependent tert-butyl hydroperoxide-induced apoptosis in hepatoma HepG2 cells

Piret, Jean-Pascal ; Arnould, Thierry ; Fuks, Bruno ; Chatelain, Pierre ; Remacle, José ; Michiels, Carine

New York, NY: Elsevier Inc

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