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Fibroblast growth factor receptor 1 ( FGFR1 ) copy number is an independent prognostic factor in non-small cell lung cancer

Tran, Thang N ; Selinger, Christina I ; Kohonen-Corish, Maija R.J ; McCaughan, Brian C ; Kennedy, Catherine W ; O’Toole, Sandra A ; Cooper, Wendy A

Lung cancer (Amsterdam, Netherlands), 2013-09, Vol.81 (3), p.462-467 [Periódico revisado por pares]

Oxford: Elsevier B.V

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Título:
Fibroblast growth factor receptor 1 ( FGFR1 ) copy number is an independent prognostic factor in non-small cell lung cancer
Autor: Tran, Thang N ; Selinger, Christina I ; Kohonen-Corish, Maija R.J ; McCaughan, Brian C ; Kennedy, Catherine W ; O’Toole, Sandra A ; Cooper, Wendy A
Assuntos: Aged ; Aged, 80 and over ; Amplification ; Biological and medical sciences ; Carcinoma, Non-Small-Cell Lung - genetics ; Carcinoma, Non-Small-Cell Lung - mortality ; Carcinoma, Non-Small-Cell Lung - pathology ; Chromogenic silver in situ hybridisation ; Dermatology ; Female ; FGFR1 ; Fibroblast growth factor receptor ; Gene Amplification ; Gene Dosage ; Hematology, Oncology and Palliative Medicine ; Humans ; Immunohistochemistry ; Lung cancer ; Lung Neoplasms - genetics ; Lung Neoplasms - mortality ; Lung Neoplasms - pathology ; Lymphatic Metastasis ; Male ; Medical sciences ; Middle Aged ; Multiple tumors. Solid tumors. Tumors in childhood (general aspects) ; Neoplasm Grading ; Neoplasm Staging ; NSCLC ; Pneumology ; Prognosis ; Pulmonary/Respiratory ; Receptor, Fibroblast Growth Factor, Type 1 - genetics ; Receptor, Fibroblast Growth Factor, Type 1 - metabolism ; Retrospective Studies ; Squamous cell carcinoma ; Tumors ; Tumors of the respiratory system and mediastinum ; Tumors of the skin and soft tissue. Premalignant lesions
É parte de: Lung cancer (Amsterdam, Netherlands), 2013-09, Vol.81 (3), p.462-467
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Abstract Fibroblast growth factor receptor 1 ( FGFR1 ) is an oncogene that can potentially be targeted by tyrosine kinase inhibitors. We aimed to investigate the prevalence and prognostic significance of alterations in FGFR1 copy number in non-small cell lung cancer (NSCLC). FGFR1 status was evaluated by chromogenic silver in situ hybridisation (ISH) in tissue microarray sections from a retrospective cohort of 304 surgically resected NSCLCs and results were correlated with the clinicopathological features and overall survival. High FGFR1 gene copy number (amplification or high-level polysomy) was significantly more frequent in squamous cell carcinomas (SCC) (24.8%) and large cell carcinomas (LCC) (25%) compared to adenocarcinomas (11.3%) ( p = 0.01 and p = 0.03 respectively). Among NSCLC there was no significant correlation between FGFR1 -positive status and other clinicopathological features including age, gender, smoking history, tumour size, lymph node status, stage, grade, vascular, lymphatic or perineural invasion. FGFR1 -positive patients showed a tendency to longer overall survival in univariate analysis ( p = 0.14). Multivariate survival analysis using Cox regression model confirmed FGFR1 -positive patients had a significant reduction in the risk of death compared to FGFR1 -negative patients (HR 0.6; p = 0.02). High FGFR1 gene copy number is a common finding in SCC and LCC and is an independent favourable prognostic factor.
Editor: Oxford: Elsevier B.V
Idioma: Inglês

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Fibroblast growth factor receptor 1 ( FGFR1 ) copy number is an independent prognostic factor in non-small cell lung cancer

Tran, Thang N ; Selinger, Christina I ; Kohonen-Corish, Maija R.J ; McCaughan, Brian C ; Kennedy, Catherine W ; O’Toole, Sandra A ; Cooper, Wendy A

Oxford: Elsevier B.V

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