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Continuous (R)-mandelic acid production in an enzyme membrane reactor

VASIC-RACKI, DJ ; JONAS, M ; WANDREY, C ; HUMMEL, W ; KULA, M.-R

Applied microbiology and biotechnology, 1989, Vol.31 (3), p.215-222 [Periódico revisado por pares]

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Título:
Continuous (R)-mandelic acid production in an enzyme membrane reactor
Autor: VASIC-RACKI, DJ ; JONAS, M ; WANDREY, C ; HUMMEL, W ; KULA, M.-R
Assuntos: Bioconversions. Hemisynthesis ; Biological and medical sciences ; bioreactors ; Biotechnology ; Fundamental and applied biological sciences. Psychology ; mathematical models ; Methods. Procedures. Technologies
É parte de: Applied microbiology and biotechnology, 1989, Vol.31 (3), p.215-222
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
Descrição: The continuous conversion of phenylglyoxylic acid to (R)-mandelic acid was performed in an enzyme membrane reactor with simultaneous coenzyme regeneration employing mandelate dehydrogenase and formate dehydrogenase. A mathematical model of the coupled enzyme reactions was formulated and applied to determine optimal conditions for (R)-mandelic acid production. The experiments and calculations showed that the optimal operational points depend strongly on enzyme kinetics. The individual kinetic parameters determined were appropriate for the description of (R)-mandelic acid production in the simultaneous two-enzyme process. Space time yields of 700 g/(l multiplied by day) were obtained at low enzyme consumption.
Editor: Berlin: Springer
Idioma: Inglês

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