Idioma:

Interleukin-1 signaling induced by Streptococcus suis serotype 2 is strain-dependent and contributes to bacterial clearance and inflammation during systemic disease in a mouse model of infection

Lavagna, Agustina ; Auger, Jean-Philippe ; Dumesnil, Audrey ; Roy, David ; Girardin, Stephen E ; Gisch, Nicolas ; Segura, Mariela ; Gottschalk, Marcelo

Veterinary research (Paris), 2019-07, Vol.50 (1), p.52-52, Article 52 [Periódico revisado por pares]

England: BioMed Central Ltd

Texto completo disponível

Citações Citado por

Enviar para

Título:
Interleukin-1 signaling induced by Streptococcus suis serotype 2 is strain-dependent and contributes to bacterial clearance and inflammation during systemic disease in a mouse model of infection
Autor: Lavagna, Agustina ; Auger, Jean-Philippe ; Dumesnil, Audrey ; Roy, David ; Girardin, Stephen E ; Gisch, Nicolas ; Segura, Mariela ; Gottschalk, Marcelo
Assuntos: Animals ; Cellular signal transduction ; Cloning ; Cytokines ; Deoxyribonucleic acid ; Development and progression ; Disease Models, Animal ; DNA ; DNA polymerase ; E coli ; Female ; Health aspects ; Hogs ; Immune response ; Immunity, Innate ; Inflammation ; Inflammation - immunology ; Inflammation - veterinary ; Interleukin-1 ; Interleukin-1 - metabolism ; Kinases ; Life Sciences ; Male ; Meningitis ; Mice ; Mice, Inbred C57BL ; Pathogenesis ; Plasmids ; Proteins ; Serogroup ; Signal Transduction ; Streptococcal infections ; Streptococcal Infections - immunology ; Streptococcal Infections - microbiology ; Streptococcal Infections - veterinary ; Streptococcus infections ; Streptococcus suis - physiology ; Swine ; Swine Diseases - immunology ; Swine Diseases - microbiology
É parte de: Veterinary research (Paris), 2019-07, Vol.50 (1), p.52-52, Article 52
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Streptococcus suis serotype 2 is an important porcine pathogen and zoonotic agent causing sudden death, septic shock and meningitis, with exacerbated inflammation being a hallmark of the infection. A rapid, effective and balanced innate immune response against S. suis is critical to control bacterial growth without causing excessive inflammation. Even though interleukin (IL)-1 is one of the most potent and earliest pro-inflammatory mediators produced, its role in the S. suis pathogenesis has not been studied. We demonstrated that a classical virulent European sequence type (ST) 1 strain and the highly virulent ST7 strain induce important levels of IL-1 in systemic organs. Moreover, bone marrow-derived dendritic cells and macrophages contribute to its production, with the ST7 strain inducing higher levels. To better understand the underlying mechanisms involved, different cellular pathways were studied. Independently of the strain, IL-1β production required MyD88 and involved recognition via TLR2 and possibly TLR7 and TLR9. This suggests that the recognized bacterial components are similar and conserved between strains. However, very high levels of the pore-forming toxin suilysin, produced only by the ST7 strain, are required for efficient maturation of pro-IL-1β via activation of different inflammasomes resulting from pore formation and ion efflux. Using IL-1R mice, we demonstrated that IL-1 signaling plays a beneficial role during S. suis systemic infection by modulating the inflammation required to control and clear bacterial burden, thus promoting host survival. Beyond a certain threshold, however, S. suis-induced inflammation cannot be counterbalanced by this signaling, making it difficult to discriminate its role.
Editor: England: BioMed Central Ltd
Idioma: Inglês

Links

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Interleukin-1 signaling induced by Streptococcus suis serotype 2 is strain-dependent and contributes to bacterial clearance and inflammation during systemic disease in a mouse model of infection

Lavagna, Agustina ; Auger, Jean-Philippe ; Dumesnil, Audrey ; Roy, David ; Girardin, Stephen E ; Gisch, Nicolas ; Segura, Mariela ; Gottschalk, Marcelo

England: BioMed Central Ltd

Buscando em bases de dados remotas. Favor aguardar.