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Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis

Lowes, D.A. ; Webster, N.R. ; Murphy, M.P. ; Galley, H.F.

British journal of anaesthesia : BJA, 2013-03, Vol.110 (3), p.472-480 [Periódico revisado por pares]

England: Elsevier Ltd

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Título:
Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis
Autor: Lowes, D.A. ; Webster, N.R. ; Murphy, M.P. ; Galley, H.F.
Assuntos: Acute Disease ; Alanine ; Animal models ; Animals ; Antioxidants ; Antioxidants - pharmacology ; Antioxidants - therapeutic use ; Biochemical markers ; Biomarkers ; Blood ; co-enzyme Q10 ; Creatinine ; Cytokines - biosynthesis ; Electron transport ; Escherichia coli ; Inflammation ; Interleukin 6 ; interleukin-10 ; Interleukin-6 - metabolism ; Kidney Function Tests ; Lipopolysaccharides ; Liver Function Tests ; Male ; Melatonin ; Melatonin - pharmacology ; Melatonin - therapeutic use ; Mitochondria ; Mitochondria - drug effects ; Multiple Organ Failure - physiopathology ; Multiple Organ Failure - prevention & control ; Organophosphorus Compounds - therapeutic use ; Oxidative stress ; Oxidative Stress - drug effects ; Oxygen Consumption - drug effects ; peptidoglycans ; Rats ; Rats, Sprague-Dawley ; Sepsis ; Sepsis - chemically induced ; Sepsis - drug therapy ; Sepsis - physiopathology ; Staphylococcus aureus ; tocopherol ; Translational Research ; Ubiquinone - analogs & derivatives ; Ubiquinone - therapeutic use
É parte de: British journal of anaesthesia : BJA, 2013-03, Vol.110 (3), p.472-480
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Descrição: Sepsis-induced organ failure is the major cause of death in critical care units, and is characterized by a massive dysregulated inflammatory response and oxidative stress. We investigated the effects of treatment with antioxidants that protect mitochondria (MitoQ, MitoE, or melatonin) in a rat model of lipopolysaccharide (LPS) plus peptidoglycan (PepG)-induced acute sepsis, characterized by inflammation, mitochondrial dysfunction and early organ damage. Anaesthetized and ventilated rats received an i.v. bolus of LPS and PepG followed by an i.v. infusion of MitoQ, MitoE, melatonin, or saline for 5 h. Organs and blood were then removed for determination of mitochondrial and organ function, oxidative stress, and key cytokines. MitoQ, MitoE, or melatonin had broadly similar protective effects with improved mitochondrial respiration (P<0.002), reduced oxidative stress (P<0.02), and decreased interleukin-6 levels (P=0.0001). Compared with control rats, antioxidant-treated rats had lower levels of biochemical markers of organ dysfunction, including plasma alanine amino-transferase activity (P=0.02) and creatinine concentrations (P<0.0001). Antioxidants that act preferentially in mitochondria reduce mitochondrial damage and organ dysfunction and decrease inflammatory responses in a rat model of acute sepsis.
Editor: England: Elsevier Ltd
Idioma: Inglês

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Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis

Lowes, D.A. ; Webster, N.R. ; Murphy, M.P. ; Galley, H.F.

England: Elsevier Ltd

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