skip to main content
Primo Search
Search in: Busca Geral

Empagliflozin suppresses hedgehog pathway, alleviates ER stress, and ameliorates hepatic fibrosis in rats

Abdalla, Nourihan ; Abo-ElMatty, Dina M ; Saleh, Sami ; Ghattas, Maivel H ; Omar, Nesreen Nabil

Scientific reports, 2023-11, Vol.13 (1), p.19046-19046, Article 19046 [Periódico revisado por pares]

London: Nature Publishing Group

Texto completo disponível

Citações Citado por
  • Título:
    Empagliflozin suppresses hedgehog pathway, alleviates ER stress, and ameliorates hepatic fibrosis in rats
  • Autor: Abdalla, Nourihan ; Abo-ElMatty, Dina M ; Saleh, Sami ; Ghattas, Maivel H ; Omar, Nesreen Nabil
  • Assuntos: Animals ; Anti-inflammatory agents ; Antioxidants ; Biochemistry ; Carbon tetrachloride ; Endoplasmic reticulum ; Fibrosis ; Gastric lavage ; Glioblastoma ; Hedgehog protein ; Hepatocellular carcinoma ; Immunosuppression ; Inflammation ; Interleukins ; Liver ; Liver cancer ; Metabolism ; mRNA ; Pharmacy ; Proteins ; Research ethics ; Signal transduction ; Stellate cells ; Tumor necrosis factor-α
  • É parte de: Scientific reports, 2023-11, Vol.13 (1), p.19046-19046, Article 19046
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Worldwide mortality from hepatic fibrosis remains high, due to hepatocellular carcinoma and end stage liver failure. The progressive nature of hepatic fibrosis from inflammation to cicatrized tissues warrants subtle intervention with pharmacological agents that hold potential. Empagliflozin (Empa), a novel hypoglycemic drug with antioxidant and anti-inflammatory properties, has lately been proposed to have additional antifibrotic activities. In the current study, we examined the antifibrotic effect of the Empa through modulating the activity of hepatic stellate cells by hedgehog (Hh) pathway. We also assessed the markers of inflammatory response and endoplasmic reticulum (ER) stress. Male Albino rats were treated with either CCl4 (0.4 mg/kg twice/week) and/or Empa (10 mg/kg/day) for eight weeks. In this study, CCl4 rats had active Hh signaling as indicated by overexpression of Patched 1, Smoothened and Glioblastoma-2. CCl4 induced ER stress as CHOP expression was upregulated and ERAD was downregulated. CCl4-induced inflammatory response was demonstrated through increased levels of TNF-α, IL-6 and mRNA levels of IL-17 while undetectable expression of IL-10. Conversely, Empa elicited immunosuppression, suppressed the expression of Hh markers, and reversed markers of ER stress. In conclusion, Empa suppressed CCl4-induced Hh signaling and proinflammatory response, meanwhile embraced ER stress in the hepatic tissues, altogether provided hepatoprotection.
  • Editor: London: Nature Publishing Group
  • Idioma: Inglês

Buscando em bases de dados remotas. Favor aguardar.