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A Comparison of the Variable Antigens Expressed by Clone IV-1 and Subgroup III of Neisseria meningitidis Serogroup A

Achtman, Mark ; Kusecek, Barica ; Morelli, Giovanna ; Eickmann, Kirsten ; Jianfu, Wang ; Crowe, Brian ; Wall, Robert A. ; Hassan-King, Musa ; Moore, Patrick S. ; Zollinger, Wendell

The Journal of infectious diseases, 1992-01, Vol.165 (1), p.53-68 [Periódico revisado por pares]

CHICAGO: The University of Chicago Press

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Título:
A Comparison of the Variable Antigens Expressed by Clone IV-1 and Subgroup III of Neisseria meningitidis Serogroup A
Autor: Achtman, Mark ; Kusecek, Barica ; Morelli, Giovanna ; Eickmann, Kirsten ; Jianfu, Wang ; Crowe, Brian ; Wall, Robert A. ; Hassan-King, Musa ; Moore, Patrick S. ; Zollinger, Wendell
Assuntos: Africa, Western - epidemiology ; Antibodies ; Antibodies, Bacterial - blood ; Antibodies, Monoclonal - immunology ; Antigenic Variation ; Antigens ; Antigens, Bacterial - analysis ; Bacteria ; Bacterial diseases ; Bacterial Proteins - analysis ; Bacterial Proteins - immunology ; Bacteriology ; Biological and medical sciences ; Blotting, Western ; Disease Outbreaks ; Electrophoresis, Polyacrylamide Gel ; Epidemics ; Epidemiology ; Epitopes ; Epitopes - analysis ; Fimbriae, Bacterial - immunology ; Fundamental and applied biological sciences. Psychology ; Gambia - epidemiology ; Humans ; Immunology ; Infectious Diseases ; Life Sciences & Biomedicine ; Lipopolysaccharides - analysis ; Lipopolysaccharides - immunology ; Major Articles ; Meningitis, Meningococcal - epidemiology ; Meningitis, Meningococcal - microbiology ; Microbiology ; Monoclonal antibodies ; Neisseria meningitidis ; Neisseria meningitidis - classification ; Neisseria meningitidis - immunology ; Pandemics ; Science & Technology ; Serotyping
É parte de: The Journal of infectious diseases, 1992-01, Vol.165 (1), p.53-68
Notas: Reprints or correspondence: Dr. Mark Achtrnan, Max-Planck Institut flir molekulare Genetik, Ihnestr. 73. 0-1000 Berlin 33, FRG.
istex:07D6A3024E4569C4DC8EEFDCA4BDD7F125C8E03F
Present addresses: Immuno AG, Orth-Donau, Austria (B.C.); Division ofCommunicable Diseases, Clinical Research Centre, Northwick Park Hospital, Harrow, UK (R.A.W.); Center for AIDS Prevention Studies, University of California, San Francisco (P.S.M.).
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Descrição: Serogroup A Neisseria meningitidis of subgroup III has caused two pandemics of meningococcal meningitis since 1966 and recently spread to East Africa. The last epidemics in West Africa in the early 1980s were caused by clone IV-I. Surface antigens of clone IV-1 strains from West Africa and subgroup III strains from both pandemic waves were analyzed. Lipopolysaccharide was stable within clone IV-1 but variable in subgroup III. Pili from clone IV-1 possessed class I epitopes, while those from subgroup III also possessed class IIa epitopes. Certain class 5 protein variants were expressed by both bacterial clones, possibly reflecting either inheritance of primeval genes or horizontal transmission. Exposure of Gambians to clone IV-1 bacteria stimulated production of bactericidal antibodies cross-reactive with subgroup III bacteria in some individuals but of type-specific antibodies in others. Gambians without bactericidal antibodies usually became healthy carriers rather than developing meningococcal disease on exposure to virulent meningococci.
Editor: CHICAGO: The University of Chicago Press
Idioma: Inglês

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A Comparison of the Variable Antigens Expressed by Clone IV-1 and Subgroup III of Neisseria meningitidis Serogroup A

Achtman, Mark ; Kusecek, Barica ; Morelli, Giovanna ; Eickmann, Kirsten ; Jianfu, Wang ; Crowe, Brian ; Wall, Robert A. ; Hassan-King, Musa ; Moore, Patrick S. ; Zollinger, Wendell

CHICAGO: The University of Chicago Press

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