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Use of itraconazole in the treatment of mucocutaneous leishmaniasis: A pilot study

Amato, Valdir S. ; Padilha, Alexandre R.S. ; Nicodemo, Antônio C. ; Duarte, Maria I.S. ; Valentini, Mario ; Uip, David E. ; Boulos, Marcos ; Neto, Vicente Amato

International journal of infectious diseases, 2000, Vol.4 (3), p.153-157 [Periódico revisado por pares]

Amsterdam: Elsevier Ltd

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Título:
Use of itraconazole in the treatment of mucocutaneous leishmaniasis: A pilot study
Autor: Amato, Valdir S. ; Padilha, Alexandre R.S. ; Nicodemo, Antônio C. ; Duarte, Maria I.S. ; Valentini, Mario ; Uip, David E. ; Boulos, Marcos ; Neto, Vicente Amato
Assuntos: Adult ; Aged ; Aged, 80 and over ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiparasitic agents ; Biological and medical sciences ; Drug Administration Schedule ; Female ; Humans ; itraconazole ; Itraconazole - therapeutic use ; Leishmaniasis, Mucocutaneous - diagnosis ; Leishmaniasis, Mucocutaneous - drug therapy ; Male ; Medical sciences ; Middle Aged ; mucocutaneous leishmaniasis ; mucosal leishmaniasis ; Pharmacology. Drug treatments ; Pilot Projects ; treatment ; Treatment Outcome
É parte de: International journal of infectious diseases, 2000, Vol.4 (3), p.153-157
Descrição: Objectives: Mucocutaneous leishmaniasis is widely distributed in Brazil, with Leishmania (Viannia) braziliensis being the major etiologic agent. The currently recommended therapy is limited by its parenteral use, high toxicity, and variable efficacy. A clinical pilot study was conducted to analyze itraconazole as an oral alternative for the treatment of mucocutaneous leishmaniasis. Methods: Ten patients were enrolled to receive 4 mg/kg per day (up to 400 mg/d) itraconazole for 6 weeks on an outpatient regimen. Diagnosis was based on clinical otorhinolaryngologic examination, folowed by a specific serologic reaction, the Montenegro test and pathologic analysis with immunohistochemical reaction. Healing of the lesions was confirmed by clinical otorhinolaryngologic examination. Side effects were monitored by general clinical assessment, hemoglobin determination, leukocyte counts, and liver function tests, all performed before, during, and 1 month after the end of treatment. Results: Six of 10 patients presented healed lesions 3 months after treatment, with a sustained therapeutic response for at least a median period of 14.5 months (range, 12–18 mo). Side effects were not observed. Conclusions: This pilot study demonstrated that itraconazole can be an effective and well-tolerated alternative for the treatment of mucocutaneous leishmaniasis. Further randomized studies and double blind controlled trials are needed to assess the benefits of this drug in the treatment of mucocutaneous leishmaniasis.
Editor: Amsterdam: Elsevier Ltd
Idioma: Inglês

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Use of itraconazole in the treatment of mucocutaneous leishmaniasis: A pilot study

Amato, Valdir S. ; Padilha, Alexandre R.S. ; Nicodemo, Antônio C. ; Duarte, Maria I.S. ; Valentini, Mario ; Uip, David E. ; Boulos, Marcos ; Neto, Vicente Amato

Amsterdam: Elsevier Ltd

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