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A survival Kit for pancreatic beta cells: stem cell factor and c-Kit receptor tyrosine kinase

Feng, Zhi-Chao ; Riopel, Matthew ; Popell, Alex ; Wang, Rennian

Diabetologia, 2015-04, Vol.58 (4), p.654-665 [Revista revisada por pares]

Berlin/Heidelberg: Springer Berlin Heidelberg

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Título:
A survival Kit for pancreatic beta cells: stem cell factor and c-Kit receptor tyrosine kinase
Autor: Feng, Zhi-Chao ; Riopel, Matthew ; Popell, Alex ; Wang, Rennian
Materias: Animals ; Cell Survival ; Chromosomes ; Diabetes ; Diabetes Mellitus - enzymology ; Diabetes Mellitus - physiopathology ; Diabetes Mellitus - therapy ; Growth factors ; Human Physiology ; Humans ; Hypoglycemic Agents - therapeutic use ; Insulin resistance ; Insulin-Secreting Cells - drug effects ; Insulin-Secreting Cells - enzymology ; Insulin-Secreting Cells - transplantation ; Internal Medicine ; Islets of Langerhans - drug effects ; Islets of Langerhans - enzymology ; Islets of Langerhans - physiopathology ; Kinases ; Ligands ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Molecular Targeted Therapy ; Pancreas ; Phenotype ; Proto-Oncogene Proteins c-kit - metabolism ; Review ; Signal transduction ; Signal Transduction - drug effects ; Stem Cell Factor - metabolism ; Stem cells
Es parte de: Diabetologia, 2015-04, Vol.58 (4), p.654-665
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descripción: The interactions between c-Kit and its ligand, stem cell factor (SCF), play an important role in haematopoiesis, pigmentation and gametogenesis. c-Kit is also found in the pancreas, and recent studies have revealed that c-Kit marks a subpopulation of highly proliferative pancreatic endocrine cells that may harbour islet precursors. c-Kit governs and maintains pancreatic endocrine cell maturation and function via multiple signalling pathways. In this review we address the importance of c-Kit signalling within the pancreas, including its profound role in islet morphogenesis, islet vascularisation, and beta cell survival and function. We also discuss the impact of c-Kit signalling in pancreatic disease and the use of c-Kit as a potential target for the development of cell-based and novel drug therapies in the treatment of diabetes.
Editor: Berlin/Heidelberg: Springer Berlin Heidelberg
Idioma: Inglés

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A survival Kit for pancreatic beta cells: stem cell factor and c-Kit receptor tyrosine kinase

Feng, Zhi-Chao ; Riopel, Matthew ; Popell, Alex ; Wang, Rennian

Berlin/Heidelberg: Springer Berlin Heidelberg

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