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Characterization complex collagen fiber architecture in knee joint using high‐resolution diffusion imaging

Wang, Nian ; Mirando, Anthony J. ; Cofer, Gary ; Qi, Yi ; Hilton, Matthew J. ; Johnson, G. Allan

Magnetic resonance in medicine, 2020-08, Vol.84 (2), p.908-919 [Periódico revisado por pares]

United States: Wiley Subscription Services, Inc

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Título:
Characterization complex collagen fiber architecture in knee joint using high‐resolution diffusion imaging
Autor: Wang, Nian ; Mirando, Anthony J. ; Cofer, Gary ; Qi, Yi ; Hilton, Matthew J. ; Johnson, G. Allan
Assuntos: Angular resolution ; Animals ; Cartilage ; Cartilage (articular) ; Cartilage, Articular - diagnostic imaging ; Collagen ; Connective tissues ; Diffusion ; Diffusion Magnetic Resonance Imaging ; Diffusion Tensor Imaging ; DTI ; Fiber orientation ; Fibers ; GQI ; Image Processing, Computer-Assisted ; Imaging ; Joints (anatomy) ; Knee ; Knee Joint - diagnostic imaging ; Ligaments ; Light microscopy ; Magnetic resonance imaging ; Meniscus ; MRI ; Muscles ; Optical microscopy ; Polarized light ; Rats ; Spatial discrimination ; Spatial resolution ; Tensors ; tractography
É parte de: Magnetic resonance in medicine, 2020-08, Vol.84 (2), p.908-919
Notas: Funding information
This work was supported by the NIH/NIBIB National Biomedical Technology Resource Center P41 EB015897 (to G.A.J.), NIH 1S10OD010683‐01 (to G.A.J.), NIH 1R01NS096720‐01A1 (to G.A.J.), 5R01AR063071‐07 (to M.J.H.), and Charles E. Putman MD Vision Award of the Department of Radiology, Duke University School of Medicine (to N.W and C.E.S.).
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Descrição: Purpose To evaluate the complex fiber orientations and 3D collagen fiber network of knee joint connective tissues, including ligaments, muscle, articular cartilage, and meniscus using high spatial and angular resolution diffusion imaging. Methods Two rat knee joints were scanned using a modified 3D diffusion‐weighted spin echo pulse sequence with the isotropic spatial resolution of 45 μm at 9.4T. The b values varied from 250 to 1250 s/mm2 with 31 diffusion encoding directions for 1 rat knee. The b value was fixed to 1000 s/mm2 with 147 diffusion encoding directions for the second knee. Both the diffusion tensor imaging (DTI) model and generalized Q‐sampling imaging (GQI) method were used to investigate the fiber orientation distributions and tractography with the validation of polarized light microscopy. Results To better resolve the crossing fibers, the b value should be great than or equal to 1000 s/mm2. The tractography results were comparable between the DTI model and GQI method in ligament and muscle. However, the tractography exhibited apparent difference between DTI and GQI in connective tissues with more complex collagen fibers network, such as cartilage and meniscus. In articular cartilage, there were numerous crossing fibers found in superficial zone and transitional zone. Tractography generated with GQI also resulted in more intact tracts in articular cartilage than DTI. Conclusion High‐resolution diffusion imaging with GQI method can trace the complex collagen fiber orientations and architectures of the knee joint at microscopic resolution.
Editor: United States: Wiley Subscription Services, Inc
Idioma: Inglês

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Characterization complex collagen fiber architecture in knee joint using high‐resolution diffusion imaging

Wang, Nian ; Mirando, Anthony J. ; Cofer, Gary ; Qi, Yi ; Hilton, Matthew J. ; Johnson, G. Allan

United States: Wiley Subscription Services, Inc

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