Idioma:

20S Proteasome Inhibitory Activity of [N-(9-Anthracenylmethyl)-1,3-propanediamine] (2,2′-Bipyridine) Palladium(II) Chloride

Kiwada, Tatsuto ; Takayama, Hiroshi ; Katakasu, Hiromu ; Ogawa, Kazuma ; Odani, Akira

Chemistry letters, 2019-08, Vol.48 (8), p.936-938 [Periódico revisado por pares]

Texto completo disponível

Citações Citado por

Título:
20S Proteasome Inhibitory Activity of [N-(9-Anthracenylmethyl)-1,3-propanediamine] (2,2′-Bipyridine) Palladium(II) Chloride
Autor: Kiwada, Tatsuto ; Takayama, Hiroshi ; Katakasu, Hiromu ; Ogawa, Kazuma ; Odani, Akira
Assuntos: Anthracene ; Cathepsin B ; Crystal structure ; Palladium ; Selectivity
É parte de: Chemistry letters, 2019-08, Vol.48 (8), p.936-938
Descrição: The new palladium(II) complex, [Pd(bpy)(AtC3)]2+, where bpy = 2,2′-bipyridine and AtC3 = N-(9-anthracenylmethyl)-1,3-propanediamine, was synthesized and characterized. The crystal structure of [Pd(bpy)(AtC3)]2+ was determined. An intramolecular π–π stacking interaction was observed between anthracene and bipyridine. [Pd(bpy)(AtC3)]2+ exhibited 20S proteasome inhibitory activity. [Pd(bpy)(AtC3)]2+ also inhibited the proteolytic activity of cathepsin B, but not that of α-chymotripsin. Thus, [Pd(bpy)(AtC3)]2+ showed moderate selectivity for proteases. The binding mode of [Pd(bpy)(AtC3)]2+ to 20S proteasome was shown to be irreversible in a washout assay.
Editor: Tokyo: The Chemical Society of Japan
Idioma: Inglês;Francês;Alemão;Japonês

Voltar para lista de resultados