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Improved reactive nanoparticles to treat dentin hypersensitivity

Toledano-Osorio, Manuel ; Osorio, Estrella ; Aguilera, Fátima S. ; Luis Medina-Castillo, Antonio ; Toledano, Manuel ; Osorio, Raquel

Acta biomaterialia, 2018-05, Vol.72, p.371-380 [Periódico revisado por pares]

England: Elsevier Ltd

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Título:
Improved reactive nanoparticles to treat dentin hypersensitivity
Autor: Toledano-Osorio, Manuel ; Osorio, Estrella ; Aguilera, Fátima S. ; Luis Medina-Castillo, Antonio ; Toledano, Manuel ; Osorio, Raquel
Assuntos: Additives ; Adolescent ; Adult ; Atomic force microscopy ; Calcium ; Calcium - chemistry ; Calcium - pharmacology ; Calcium phosphates ; Cervical dentin ; Citric acid ; Demineralization ; Demineralizing ; Dentin ; Dentin - metabolism ; Dentin - pathology ; Dentin Sensitivity - drug therapy ; Dentin Sensitivity - metabolism ; Dentin Sensitivity - pathology ; DMA ; Doxycycline ; Doxycycline - chemistry ; Doxycycline - pharmacology ; Drug Carriers - chemistry ; Drug Carriers - pharmacology ; Drug Evaluation, Preclinical ; Emission analysis ; Energy storage ; Female ; Field emission microscopy ; Fluid dynamics ; Fluid flow ; Humans ; Hypersensitivity ; Loss modulus ; Male ; Mechanical properties ; Nanoparticles ; Nanoparticles - chemistry ; Nanoparticles - therapeutic use ; Nanostructured materials ; Occlusion ; Pain ; Patients ; Permeability ; Reduction ; Remineralization ; Scanning electron microscopy ; Tubules ; Viscoelasticity ; Zinc ; Zinc - chemistry ; Zinc - pharmacology
É parte de: Acta biomaterialia, 2018-05, Vol.72, p.371-380
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: [Display omitted] The aim of this study was to evaluate the effectiveness of different nanoparticles-based solutions for dentin permeability reduction and to determine the viscoelastic performance of cervical dentin after their application. Four experimental nanoparticle solutions based on zinc, calcium or doxycycline-loaded polymeric nanoparticles (NPs) were applied on citric acid etched dentin, to facilitate the occlusion and the reduction of the fluid flow at the dentinal tubules. After 24 h and 7 d of storage, cervical dentin was evaluated for fluid filtration. Field emission scanning electron microscopy, energy dispersive analysis, AFM and Nano-DMA analysis were also performed. Complex, storage, loss modulus and tan delta (δ) were assessed. Doxycycline-loaded NPs impaired tubule occlusion and fluid flow reduction trough dentin. Tubules were 100% occluded in dentin treated with calcium-loaded NPs or zinc-loaded NPs, analyzed at 7 d. Dentin treated with both zinc-NPs and calcium-NPs attained the highest reduction of dentinal fluid flow. Moreover, when treating dentin with zinc-NPs, complex modulus values attained at intertubular and peritubular dentin were higher than those obtained after applying calcium-NPs. Zinc-NPs are then supposed to fasten active dentin remodeling, with increased maturity and high mechanical properties. Zinc-based nanoparticles are then proposed for effective dentin remineralization and tubular occlusion. Further research to finally prove for clinical benefits in patients with dentin hypersensitivity using Zn-doped nanoparticles is encouraged. Erosion from acids provokes dentin hypersensitivity (DH) which presents with intense pain of short duration. Open dentinal tubules and demineralization favor DH. Nanogels based on Ca-nanoparticles and Zn-nanoparticles produced an efficient reduction of fluid flow. Dentinal tubules were filled by precipitation of induced calcium-phosphate deposits. When treating dentin with Zn-nanoparticles, complex modulus values attained at intertubular and peritubular dentin were higher than those obtained after applying Ca-nanoparticles. Zn-nanoparticles are then supposed to fasten active dentin remodeling, with increased maturity and high mechanical properties. Zinc-based nanogels are, therefore, proposed for effective dentin remineralization and tubular occlusion. Further research to finally prove for clinical benefits in patients with dentin hypersensitivity using Zn-doped nanogels is encouraged.
Editor: England: Elsevier Ltd
Idioma: Inglês

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Improved reactive nanoparticles to treat dentin hypersensitivity

Toledano-Osorio, Manuel ; Osorio, Estrella ; Aguilera, Fátima S. ; Luis Medina-Castillo, Antonio ; Toledano, Manuel ; Osorio, Raquel

England: Elsevier Ltd

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