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Potent small molecule CCR1 antagonists

KATH, John C ; BRISSETTE, William H ; MARTIN, William H ; MCELROY, Eric B ; MCGLYNN, Molly A ; PARADIS, Timothy J ; POSS, Christopher S ; STOCK, Ingrid A ; TYLASKA, Laurie A ; DEYE ZHENG ; BROWN, Matthew F ; CONKLYN, Maryrose ; DIRICO, Amy P ; DORFF, Peter ; GLADUE, Ronald P ; LILLIE, Brett M ; LIRA, Paul D ; MAIRS, Erin N

Bioorganic & medicinal chemistry letters, 2004-05, Vol.14 (9), p.2169-2173 [Periódico revisado por pares]

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Título:
Potent small molecule CCR1 antagonists
Autor: KATH, John C ; BRISSETTE, William H ; MARTIN, William H ; MCELROY, Eric B ; MCGLYNN, Molly A ; PARADIS, Timothy J ; POSS, Christopher S ; STOCK, Ingrid A ; TYLASKA, Laurie A ; DEYE ZHENG ; BROWN, Matthew F ; CONKLYN, Maryrose ; DIRICO, Amy P ; DORFF, Peter ; GLADUE, Ronald P ; LILLIE, Brett M ; LIRA, Paul D ; MAIRS, Erin N
Assuntos: Biological and medical sciences ; Cell Line ; Humans ; Immunomodulators ; Medical sciences ; Pharmacology. Drug treatments ; Receptors, CCR1 ; Receptors, Chemokine - antagonists & inhibitors ; Structure-Activity Relationship
É parte de: Bioorganic & medicinal chemistry letters, 2004-05, Vol.14 (9), p.2169-2173
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: The present manuscript details structure-activity relationship studies of lead structure 1, which led to the discovery of CCR1 antagonists >100-fold more potent than 1.
Editor: Oxford: Elsevier
Idioma: Inglês

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