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Clostridium difficile outbreak caused by NAP1/BI/027 strain and non-027 strains in a Mexican hospital

Morfin-Otero, Rayo ; Garza-Gonzalez, Elvira ; Aguirre-Diaz, Sara A. ; Escobedo-Sanchez, Rodrigo ; Esparza-Ahumada, Sergio ; Perez-Gomez, Hector R. ; Petersen-Morfin, Santiago ; Gonzalez-Diaz, Esteban ; Martinez-Melendez, Adrian ; Rodriguez-Noriega, Eduardo

The Brazilian journal of infectious diseases, 2016-01, Vol.20 (1), p.8-13 [Periódico revisado por pares]

Brazil: Elsevier Editora Ltda

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Título:
Clostridium difficile outbreak caused by NAP1/BI/027 strain and non-027 strains in a Mexican hospital
Autor: Morfin-Otero, Rayo ; Garza-Gonzalez, Elvira ; Aguirre-Diaz, Sara A. ; Escobedo-Sanchez, Rodrigo ; Esparza-Ahumada, Sergio ; Perez-Gomez, Hector R. ; Petersen-Morfin, Santiago ; Gonzalez-Diaz, Esteban ; Martinez-Melendez, Adrian ; Rodriguez-Noriega, Eduardo
Assuntos: 027 strain ; Adolescent ; Adult ; Aged ; Bacterial Typing Techniques ; Case-Control Studies ; Causes of ; Clostridium difficile ; Clostridium difficile - classification ; Clostridium Infections - epidemiology ; Clostridium Infections - microbiology ; Cross Infection - epidemiology ; Cross Infection - microbiology ; Disease Outbreaks ; Epidemics ; Female ; Health aspects ; Humans ; Identification and classification ; Infection control ; INFECTIOUS DISEASES ; Male ; Mexico ; Mexico - epidemiology ; Middle Aged ; Original ; Outbreak ; Real-Time Polymerase Chain Reaction ; Risk Factors ; Severity of Illness Index ; Young Adult
É parte de: The Brazilian journal of infectious diseases, 2016-01, Vol.20 (1), p.8-13
Notas: Members for the Hospital Civil de Guadalajara, Fray Antonio Alcalde Clostridium difficile Team were given in Appendix A.
Descrição: Clostridium difficile infections caused by the NAP1/B1/027 strain are more severe, difficult to treat, and frequently associated with relapses. A case–control study was designed to examine a C. difficile infection (CDI) outbreak over a 12-month period in a Mexican hospital. The diagnosis of toxigenic CDI was confirmed by real-time polymerase chain reaction, PCR (Cepheid Xpert C. difficile/Epi). During the study period, 288 adult patients were evaluated and 79 (27.4%) patients had confirmed CDI (PCR positive). C. difficile strain NAP1/B1/027 was identified in 31 (39%) of the patients with confirmed CDI (240 controls were included). Significant risk factors for CDI included any underlying disease (p<0.001), prior hospitalization (p<0.001), and antibiotic (p<0.050) or steroid (p<0.001) use. Laboratory abnormalities included leukocytosis (p<0.001) and low serum albumin levels (p<0.002). Attributable mortality was 5%. Relapses occurred in 10% of patients. Risk factors for C. difficile NAP1/B1/027 strain infections included prior use of quinolones (p<0.03). Risk factors for CDI caused by non-027 strains included chronic cardiac disease (p<0.05), chronic renal disease (p<0.009), and elevated serum creatinine levels (p<0.003). Deaths and relapses were most frequent in the 027 group (10% and 19%, respectively). C. difficile NAP1/BI/027 strain and non-027 strains are established pathogens in our hospital. Accordingly, surveillance of C. difficile infections is now part of our nosocomial prevention program.
Editor: Brazil: Elsevier Editora Ltda
Idioma: Inglês;Português

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Clostridium difficile outbreak caused by NAP1/BI/027 strain and non-027 strains in a Mexican hospital

Morfin-Otero, Rayo ; Garza-Gonzalez, Elvira ; Aguirre-Diaz, Sara A. ; Escobedo-Sanchez, Rodrigo ; Esparza-Ahumada, Sergio ; Perez-Gomez, Hector R. ; Petersen-Morfin, Santiago ; Gonzalez-Diaz, Esteban ; Martinez-Melendez, Adrian ; Rodriguez-Noriega, Eduardo

Brazil: Elsevier Editora Ltda

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