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Hepatobiliary and pancreatic: Comparison between Chinese herbal medicine and Western medicine-induced liver injury of 1985 patients

Zhu, Yun ; Niu, Ming ; Chen, Jing ; Zou, Zheng-sheng ; Ma, Zhi-jie ; Liu, Shu-hong ; Wang, Rui-lin ; He, Ting-ting ; Song, Hai-bo ; Wang, Zhong-xia ; Pu, Shi-biao ; Ma, Xiao ; Wang, Li-fu ; Bai, Zhao-fang ; Zhao, Yan-ling ; Li, Yong-gang ; Wang, Jia-bo ; Xiao, Xiao-he

Journal of gastroenterology and hepatology, 2016-08, Vol.31 (8), p.1476-1482 [Periódico revisado por pares]

Australia: Blackwell Publishing Ltd

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Título:
Hepatobiliary and pancreatic: Comparison between Chinese herbal medicine and Western medicine-induced liver injury of 1985 patients
Autor: Zhu, Yun ; Niu, Ming ; Chen, Jing ; Zou, Zheng-sheng ; Ma, Zhi-jie ; Liu, Shu-hong ; Wang, Rui-lin ; He, Ting-ting ; Song, Hai-bo ; Wang, Zhong-xia ; Pu, Shi-biao ; Ma, Xiao ; Wang, Li-fu ; Bai, Zhao-fang ; Zhao, Yan-ling ; Li, Yong-gang ; Wang, Jia-bo ; Xiao, Xiao-he
Assuntos: Adult ; Biliary Tract Diseases - chemically induced ; Biliary Tract Diseases - diagnosis ; Biliary Tract Diseases - mortality ; causality assessment ; Chemical and Drug Induced Liver Injury - diagnosis ; Chemical and Drug Induced Liver Injury - etiology ; Chemical and Drug Induced Liver Injury - mortality ; Chinese herbal medicine ; drug-induced liver injury ; Drugs, Chinese Herbal - adverse effects ; Female ; Hospitalization ; Humans ; Male ; Medicine, Chinese Traditional - adverse effects ; Middle Aged ; Pancreatic Diseases - chemically induced ; Pancreatic Diseases - diagnosis ; Pancreatic Diseases - mortality ; Polygonum multiflorum ; Prognosis ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Time Factors
É parte de: Journal of gastroenterology and hepatology, 2016-08, Vol.31 (8), p.1476-1482
Notas: istex:A5B48529532DD51E726BE7AA5DD984FCF67074A9
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ArticleID:JGH13323
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Background and Aim Chinese herbal medicine (CHM), as well as Western medicine (WM), is an important cause of drug‐induced liver injury (DILI). However, the differences between CHM and WM as agents implicated in liver injury have rarely been reported. Methods Overall, 1985 (2.05%) DILI cases were retrospectively collected from the 96 857 patients hospitalized because of liver dysfunction in the 302 Military Hospital between January 2009 and January 2014. Results In all the enrolled patients with DILI, CHM was implicated in 563 cases (28.4%), while 870 cases (43.8%) were caused by WM and the remaining patients (27.8%) by the combination of WM and CHM. Polygonum multiflorum was the major implicated CHM. Compared with WM, the cases caused by CHM showed more female (51 vs 71%, P < 0.001) and positive rechallenge (6.1 vs 8.9%, P = 0.046), a much greater proportion of hepatocellular injury (62.2 vs 88.5%, P < 0.001), and a higher mortality (2.8 vs 4.8%, P = 0.042); however, no differences in the rates of chronic DILI and ALF were found (12.9 vs 12.4%, P = 0.807; 7.6 vs 7.6%, P = 0.971). Based on Roussel Uclaf Causality Assessment Method, 75.6% of cases caused by CHM were classified as probable and only 16.6% as highly probable, significantly different from WM (38.4 and 60.3%, all P < 0.001). Conclusions The causal relationship between CHM and liver injury is much complex, and the clinical characteristics of DILI caused by CHM differ from those caused by WM.
Editor: Australia: Blackwell Publishing Ltd
Idioma: Inglês

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Hepatobiliary and pancreatic: Comparison between Chinese herbal medicine and Western medicine-induced liver injury of 1985 patients

Zhu, Yun ; Niu, Ming ; Chen, Jing ; Zou, Zheng-sheng ; Ma, Zhi-jie ; Liu, Shu-hong ; Wang, Rui-lin ; He, Ting-ting ; Song, Hai-bo ; Wang, Zhong-xia ; Pu, Shi-biao ; Ma, Xiao ; Wang, Li-fu ; Bai, Zhao-fang ; Zhao, Yan-ling ; Li, Yong-gang ; Wang, Jia-bo ; Xiao, Xiao-he

Australia: Blackwell Publishing Ltd

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