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Genomic Organization of the CC Chemokine MIP-3α/CCL20/LARC/EXODUS/SCYA20, Showing Gene Structure, Splice Variants, and Chromosome Localization

Nelson, Robin T. ; Boyd, James ; Gladue, Ronald P. ; Paradis, Timothy ; Thomas, Ranjeny ; Cunningham, Ann C. ; Lira, Paul ; Brissette, William H. ; Hayes, Lisa ; Hames, Lynn M. ; Neote, Kuldeep S. ; McColl, Shaun R.

Genomics (San Diego, Calif.), 2001-04, Vol.73 (1), p.28-37 [Periódico revisado por pares]

San Diego, CA: Elsevier Inc

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  • Título:
    Genomic Organization of the CC Chemokine MIP-3α/CCL20/LARC/EXODUS/SCYA20, Showing Gene Structure, Splice Variants, and Chromosome Localization
  • Autor: Nelson, Robin T. ; Boyd, James ; Gladue, Ronald P. ; Paradis, Timothy ; Thomas, Ranjeny ; Cunningham, Ann C. ; Lira, Paul ; Brissette, William H. ; Hayes, Lisa ; Hames, Lynn M. ; Neote, Kuldeep S. ; McColl, Shaun R.
  • Assuntos: Biological and medical sciences ; CD4 antigen ; Fundamental and applied biological sciences. Psychology ; Genes. Genome ; MIP3^a/CCL20 gene ; Molecular and cellular biology ; Molecular genetics
  • É parte de: Genomics (San Diego, Calif.), 2001-04, Vol.73 (1), p.28-37
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-1
    content type line 23
  • Descrição: We describe the genomic organization of a recently identified CC chemokine, MIP3α/CCL20 (HGMW-approved symbol SCYA20). The MIP-3α/CCL20 gene was cloned and sequenced, revealing a four exon, three intron structure, and was localized by FISH analysis to 2q35–q36. Two distinct cDNAs were identified, encoding two forms of MIP-3α/CCL20, Ala MIP-3α/CCL20 and Ser MIP-3α/CCL20, that differ by one amino acid at the predicted signal peptide cleavage site. Examination of the sequence around the boundary of intron 1 and exon 2 showed that use of alternative splice acceptor sites could give rise to Ala MIP-3α/CCL20 or Ser MIP-3α/CCL20. Both forms of MIP-3α/CCL20 were chemically synthesized and tested for biological activity. Both flu antigen plus IL-2-activated CD4+ and CD8+ T lymphoblasts and cord blood-derived dendritic cells responded to Ser and Ala MIP-3α/CCL20. T lymphocytes exposed only to IL-2 responded inconsistently, while no response was detected in naive T lymphocytes, monocytes, or neutrophils. The biological activity of Ser MIP-3α/CCL20 and Ala MIP-3α/CCL20 and the tissue-specific preference of different splice acceptor sites are not yet known.
  • Editor: San Diego, CA: Elsevier Inc
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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