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Ideal benznidazole dose regimen in chronic chagasic patients: a systematic review

Frade, Virgínia Paula; Simões, Nathália Soares; Baldoni, Nayara Ragi; Sanches, Cristina; Oliveira, Cláudia Di Lorenzo

Revista do Instituto de Medicina Tropical de São Paulo; Vol. 62 (2020); e52

Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo 2020-08-21

Acesso online

  • Título:
    Ideal benznidazole dose regimen in chronic chagasic patients: a systematic review
  • Autor: Frade, Virgínia Paula; Simões, Nathália Soares; Baldoni, Nayara Ragi; Sanches, Cristina; Oliveira, Cláudia Di Lorenzo
  • Assuntos: Benznidazole; Chagas Disease; Drug Therapy; Chronic Phase
  • É parte de: Revista do Instituto de Medicina Tropical de São Paulo; Vol. 62 (2020); e52
  • Descrição: The present study aimed to review the existing literature and to evaluate the best dose regimen for benznidazole in adult patients with Chagas disease in the chronic phase. A systematic review was conducted followed by meta-analysis. Searches were performed in four databases, to include studies published until May 2019. The descriptors used were: “Chagas disease”, “benznidazole”, “Drug Therapy”, “Pharmacokinetics”, “Dose-response relationship, drug” and “Chronic disease”. The meta-analysis compared studies using the standard dose of 5 mg/kg/day for 30 or 60 days. A total of 608 articles were found, 23 of which were considered eligible for this review and nine were included in the meta-analysis. The studies selected and analyzed were published between 1996 and 2018, with various benznidazole dose regimens, ranging from 2.5 mg/kg/day to 10 mg/kg/day, for 30 to 80 days of treatment. The results pointed to a great diversity of dose regimens, thus there is no consensus on the optimal dose regimen for benznidazole in the chronic phase of Chagas disease.
  • Títulos relacionados: https://www.revistas.usp.br/rimtsp/article/view/173923/162894; https://www.revistas.usp.br/rimtsp/article/view/173923/162896
  • Editor: Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
  • Data de criação/publicação: 2020-08-21
  • Formato: Adobe PDF
  • Idioma: Inglês
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