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Tropomyosin receptor kinase (TRK) biology and the role of NTRK gene fusions in cancer

Amatu, A ; Sartore-Bianchi, A ; Bencardino, K ; Pizzutilo, E G ; Tosi, F ; Siena, S

Annals of oncology, 2019-11, Vol.30 (Suppl_8), p.viii5-viii15 [Periódico revisado por pares]

England: Oxford University Press

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Título:
Tropomyosin receptor kinase (TRK) biology and the role of NTRK gene fusions in cancer
Autor: Amatu, A ; Sartore-Bianchi, A ; Bencardino, K ; Pizzutilo, E G ; Tosi, F ; Siena, S
Assuntos: Animals ; Gene Fusion ; Humans ; Neoplasms - enzymology ; Neoplasms - genetics ; Oncogene Proteins, Fusion - genetics ; Oncogene Proteins, Fusion - metabolism ; Protein Kinases - genetics ; Protein Kinases - metabolism ; Receptor Protein-Tyrosine Kinases - genetics ; Receptor Protein-Tyrosine Kinases - metabolism ; Receptor, trkA - genetics ; Receptor, trkA - metabolism ; Reviews ; Signal Transduction
É parte de: Annals of oncology, 2019-11, Vol.30 (Suppl_8), p.viii5-viii15
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
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A. Amatu and A. Sartore-Bianchi contributed equally to this work.
Descrição: The tropomyosin receptor kinase (TRK) family of receptor tyrosine kinases are encoded by NTRK genes and have a role in the development and normal functioning of the nervous system. Since the discovery of an oncogenic NTRK gene fusion in colorectal cancer in 1986, over 80 different fusion partner genes have been identified in a wide array of adult and paediatric tumours, providing actionable targets for targeted therapy. This review describes the normal function and physiology of TRK receptors and the biology behind NTRK gene fusions and how they act as oncogenic drivers in cancer. Finally, an overview of the incidence and prevalence of NTRK gene fusions in various types of cancers is discussed.
Editor: England: Oxford University Press
Idioma: Inglês

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Tropomyosin receptor kinase (TRK) biology and the role of NTRK gene fusions in cancer

Amatu, A ; Sartore-Bianchi, A ; Bencardino, K ; Pizzutilo, E G ; Tosi, F ; Siena, S

England: Oxford University Press

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